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Thorunn Eliasdottir, David Bragason, Sveinn Hardarson, Einar Stefánsson; Retinal Oxygen Saturation is Affected in Central Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2013;54(15):46.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of central retinal vein occlusion (CRVO) on retinal vessel oxygen saturation.
The Oxymap T1 retinal oximeter (Oxymap ehf., Reykjavik, Iceland) is based on a fundus camera and analysis software. It simultaneously captures images of the retinal vessels at 570 nm and 600 nm for calculation of hemoglobin oxygen saturation. The mean oxygen saturation in retinal arterioles and venules of both eyes was measured in 11 patients with unilateral CRVO before treatment. One patient was followed over a period of five months.
In the 11 CRVO eyes, the mean venular oxygen saturation was 24 ± 22% (mean±standard deviation) compared with 57 ± 8% in fellow eyes (p= 0.004, paired t-test). In the CRVO eye with the greatest variability, the venous saturation ranged from 8% to 63%. In CRVO eyes, the mean retinal arteriolar oxygen saturation was 96 ± 6 % vs. 94 ± 6 % in fellow eyes (p=0.3).
CRVO eyes had lower mean oxygen saturation in retinal venules than fellow eyes. The variation of venular oxygen saturation was substantial within each eye. The difference in arteriolar saturation was not significant. The reduction in venular saturation indicates compromised retinal blood flow following a central retinal vein occlusion.
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