World-wide genome-wide association study for exfoliation syndrome identifies 4 novel genetic loci. Open Access

Tin Aung; Mineo Ozaki; Francesca Pasutto; Rand R Allingham; Unnur Thorsteinsdottir; Jamie E Craig; Fotis Topouzis; Yuri Astakhov; Periasamy Sundaresan; Chiea-Chuen Khor

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Complement genes are differentially expressed in late age-related macular degeneration (AMD) and only in the neurosensory retina Open Access

Dwight Stambolian; Christine A Curcio; David Cho; James A. Kimble; Jeffrey D Messinger; Randy Zauhar; Mingyao Li

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Identification of 23 novel candidate genes for inherited retinal diseases in the European Retinal Disease Consortium Open Access

Galuh D.N. Astuti; Tamar Ben-Yosef; Susanne Kohl; Rando Allikmets; Graeme C.M. Black; Shomi S Bhattacharya; Christian P Hamel; M Imran Khan; Lonneke Haer-Wigman; Frans P Cremers

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Gene-based analyses of whole-genome interaction studies of refractive error: results from the Consortium for Refractive Error and Myopia Open Access

Robert Wojciechowski; Qiao Fan; Pirro G Hysi; Virginie JM Verhoeven; Jeremy A Guggenheim; Ching-Yu Cheng; Caroline C W Klaver; Christopher J Hammond; Seang-Mei Saw

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Analyses of low-frequency and rare variants associated with intraocular pressure Open Access

Adriana I Iglesias; Henriet Springelkamp; Sven J van der Lee; Najaf Amin; Wilfred van Ijcken; André G Uitterlinden; Pirro G Hysi; Christopher J Hammond; Terry Gaasterland; Caroline C W Klaver; Cornelia van Duijn

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Selective wiring is not needed for color opponency in midget ganglion cells Open Access

Lauren E Wool; Joanna D Crook; Orin Packer; Qasim Zaidi; Dennis M Dacey

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Single Cell Transcriptional Classification of Primate Retinal Ganglion Cells Open Access

Karl Murray; Alex Nord; Dennis M Dacey; W. Martin Usrey

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Spiking and non-spiking mechanisms control ganglion cell excitatory input at different contrasts and temporal frequencies Open Access

Ben Murphy-Baum; William Rowland Taylor

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Role of GABA_A-receptor mediated presynaptic inhibition in shaping ON ganglion cell responses Open Access

Raunak Sinha; Mrinalini Hoon; Rachel O Wong; Fred Rieke

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Insulin stimulates retinal ganglion cell dendrite regeneration through activation of the mammalian target of rapamycin complex 1and complex 2 Open Access

Jessica Agostinone; Adriana Di Polo

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Machine Learning for Optic Disc Evaluation: Modelling the GONE dataset Open Access

Jason Ha; Behzad Aliahmad; Yu Xiang George Kong; Michael Coote; Marc Sarossy

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Portable non-mydriatic imaging: a useful tool in a tele-glaucoma assessment Open Access

Tyson N. Kim; Suman S Thapa; Indira Paudyal; Leslie Niziol; Shreya Shrestha; Ian F Pitha; Pradeep Y Ramulu; Alan L Robin; Maria A Woodward; Paula Anne Newman-Casey

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Investigating the relationship between changes in retinal nerve fiber layer (RNFL) thickness and visual field (VF) damage in glaucoma patients with existing visual field loss Open Access

Luke J Saunders; Alexa Li; Akram Belghith; Felipe A Medeiros; Jeffrey L Goldberg; Jeffrey M Liebmann; Christopher A Girkin; Christopher Bowd; Robert N Weinreb; Linda M Zangwill

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Macula Structure Function Relationships Incorporating the Stimulus Area Open Access

Nimesh Bhikhu Patel; Ronald S Harwerth

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Time outdoors, light exposure, and refractive error Open Access

Donald O Mutti

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Retinal shape and structure of fovea due to development and growth Open Access

Christopher Anderson Clark

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The development of colour discrimination Open Access

Caterina Ripamonti

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Development of visual acuity and visual sensitivity in human infants Open Access

Angela M Brown

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The development of binocular function in infancy and early childhood Open Access

T. Rowan Candy

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

AAV-mediated gene augmentation restores retinal function and vision in the canine model of NPHP5 Leber congenital amaurosis Open Access

Gustavo D Aguirre; Artur V Cideciyan; Sanford L. Boye; Simone Iwabe; Valerie Dufour; Felipe Pompeo Marinho; Louise M Downs; William Hauswirth; Samuel G Jacobson; William A Beltran

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Intraocular gene expression and functional safety evaluation following intravitreal delivery of cone specific GFP-expressing AAV vectors in nonhuman primates Open Access

Kathryn W Woodburn; Steven J Samuelsson; Sharmila Vijay; Thomas Walter Chalberg; Vernard Woodley; Jordan Attwood; Matthew S Lawrence; Mehdi Gasmi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Micro-RNA induced silencing of cytotoxic transgenes leads to increased recombinant adeno-associated virus (AAV) titers Open Access

Chris Reid; William Hauswirth; Daniel M Lipinski

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Endothelin Receptor Mediated Neurodegeneration in a Rodent Model of Glaucoma. Open Access

Raghu R Krishnamoorthy; Alena Z Minton; Shaoqing He; Nolan Robert McGrady; Dorota L Stankowska

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Long term vision results following retinal gene therapy for choroideremia Open Access

Robert E MacLaren; Thomas L Edwards; Jasleen Jolly; Alun R Barnard; Kanmin Xue; Susan Downes; Graham E Holder; Graeme C.M. Black; Andrew J Lotery; Andrew Webster; Miguel Seabra

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

HUMANIN G (HNG) REDUCES MITOCHONDRIAL (mt) DNA-MEDIATED APOPTOSIS AND AUTOPHAGY IN AGE-RELATED MACULAR DEGENERATION (AMD) ARPE-19 CYBRIDS; IMPLICATIONS FOR THERAPEUTICS Open Access

Sonali R Nashine; Baruch D Kuppermann; Cristina M Kenney

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Reduction in the Bacterial Load on the Skin in a Clinical Setting Open Access

David W Stroman; Keri Mintun; Arthur B Epstein; Crystal Brimer; Chirag Patel; James Branch; Kathryn K Najafi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ocular Microbiome: Fact or Fiction? Open Access

Stephanie Wan; Aaron Sullivan; Peyton Shieh; David Evans; Carolyn Bertozzi; Suzanne M J Fleiszig

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Sjögren-like Lacrimal Keratoconjunctivitis in Germ-Free Mice Open Access

Changjun Wang; Mahira Zaheer; Fang Bian; Robert A Britton; Stephen C Pflugfelder; Cintia S de Paiva

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Viral double-strand RNA increases the membrane-associated mucin mRNA expression in immortalized corneal and conjunctival epithelium Open Access

Yuriko Ban; Tomoyo Fukuyama; Chie Sotozono; Shigeru Kinoshita

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A New Clinical Score System to Classify the Severity of Limbal Stem Cell Deficiency Open Access

Carolina Aravena; Tahir Kansu Bozkurt; Pichaya Chuephanich; chantaka Supiyaphun; Fei Yu; Sophie Xiaohui Deng

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

miRs-103/107 regulate macropinocytosis in limbal/corneal epithelia Open Access

Robert M Lavker; Jong Kook Park; Julia Katsnelson; Wending Yang; CongCong He; Han Peng

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Novel Nanoconjugates for Gene Therapy Normalization of Cultured Human Diabetic Limbal Epithelial Cells Open Access

Andrei A Kramerov; Pallavi Gangalum; Hui Ding; Julia Y Ljubimova; Alexander V Ljubimov

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The top 10 findings from the RIDE/RISE trials of ranibizumab in patients with diabetic macular edema Open Access

Rishi P Singh; Lisa Tuomi; Ivaylo Stoilov

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Shape Discrimination Hyperacuity (SDH) Improvement After Treatment of Diabetic Macular Edema (DME): One-Year Results of the DRAMA Study Open Access

Yi-Zhong Wang; Yu-Guang He; Karl G Csaky; Luis Rodriguez; Paulina Mejia; Song Zhang; Michael B Bartlett

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Aqueous vascular endothelial growth factor after bimonthly intravitreal injection of ranibizumab or aflibercept in patients with diabetic macular edema Open Access

Osamu Sawada; Yusuke Ichiyama; Yuka Ito; Masato Fujikawa; Masashi Kakinoki; Tomoko Sawada; Yoshitsugu Saishin; Masahito Ohji

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Intravitreous Plasma Kallikrein (PK) Inhibition for Diabetic Macular Edema: A Phase 1 Study of the Novel PK Inhibitor KVD001 Open Access

Jennifer K Sun; Raj K Maturi; David S Boyer; John A Wells; Victor H Gonzalez; Robert Tansley; Helen Hernandez; Lloyd P Aiello

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The Tie2 Activator AKB-9778, Used In Combination With Ranibizumab, Enhances Reduction Of Diabetic Macular Edema Compared To Ranibizumab Monotherapy Open Access

Arshad Khanani

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

RNA editing shows differences between macular and peripheral regions of human retina and supporting tissues Open Access

David Cho; Christine A Curcio; Dwight Stambolian; Mingyao Li

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A high-resolution view of the human retina miRNome Open Access

Sandro Banfi; Marianthi Karali; Maria Persico; Margherita Mutarelli; Annamaria Carissimo; Mariateresa Pizzo; Concetta Ambrosio; Michele Pinelli; Diego di Bernardo

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Retinal transcriptome signatures associated with age-related macular degeneration Open Access

Rinki Ratnapriya; Ashley Walton; Margaret Starostik; Sandra Rocio Montezuma; Deborah A Ferrington; Anand Swaroop

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Transcriptional control of glaucoma pathogenesis. Open Access

Dorota Skowronska-Krawczyk; Ling zhao; Jie Zhu; Cindy Wen; Maryam Jafari; Sherrina Patel; Michael Ai; Robert N Weinreb; Kang Zhang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Identifying Signature Profiles of Transcription Factors in Human and Mouse Models of Retinal Disease Open Access

Ana Maria Olivares; Juliana Veira; Kyle Flattery; Margaux Morrisson; Margaret M DeAngelis; Neena B Haider

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Microarray analysis of microRNA expression patterns involved in Aβ-induced retinal degeneration Open Access

Peirong Huang; Te Liu; Xueting Luo; Xiaodong Sun

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Alternative splicing in the retina in a large family of genes is regulated by a single trans locus Open Access

J M Nickerson; Felix L Struebing; Shanu Markand; Kevin Donaldson; Salma Ferdous; Jeffrey H Boatright; Eldon E Geisert

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ultraviolet A/Riboflavin Collagen Cross-linking for Conjunctiva Open Access

Ahmad Kheirkhah; Vadrevu K Raju; Pedram Hamrah; Reza Dana

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Double Docking Technique for Femtosecond Laser-Assisted Deep Anterior Lamellar Keratoplasty Open Access

Eric Gabison; Damien Guindolet; Diem Trang Nguyen; Serge Doan; Isabelle Cochereau

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Outcomes of complex Descemet’s Stripping Endothelial Keratoplasty Open Access

Chantaka Supiyaphun; Neil vyas; Pichaya Chuephanich; Tahir Kansu Bozkurt; Dr. Carolina Aravena; Fei Yu; Anthony J Aldave; Sophie Xiaohui Deng

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Long-term changes of corneal higher-order aberrations after Descemet’s Membrane Endothelial Keratoplasty
Open Access

Friedrich E Kruse; Anja Katharina Gruenert; Michael Rudolph; Julia Marina Weller; Johannes Menzel-Severing; Theofilos Tourtas

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Refractive outcomes after descemet stripping automated endothelial keratoplasty surgery associated with graft thickness Open Access

Natalie Cheung

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Analysis of Corneal Endothelial Remodeling post Descemet`s Membrane Endothelial Keratoplasty by Scanning-Slit Wide-Field Contact Specular Microscopy Open Access

Tsutomu Inatomi; Hiroshi Tanaka; Chie Sotozono; Shigeru Kinoshita

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Local Circadian Clocks at the Interface of Ocular Physiology Open Access

Joseph C Besharse

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The Legend of Central Serous Chorioretinopathy Open Access

Lawrence A. Yannuzzi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Aqueous humor dynamics in health and disease Open Access

Carol B Toris

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Fluid shifts in microgravity: The visual impairment and intracranial pressure
syndrome in U.S. astronauts Open Access

Christian Otto

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

What has genomics taught us about aqueous humor dynamics, cerebral spinal fluid dynamics and ocular perfusion pressure? Open Access

Louis R Pasquale

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Pharmacokinetics of Chemotherapy Delivery for Retinoblastoma Open Access

David H Abramson

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Drug delivery for ocular surface malignancies Open Access

Jacob Pe'er

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Fluidics: Drivers for selective drug delivery into the eye Open Access

Uday B Kompella

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The yin and yang of the complement cascade in glaucoma – the importance of timing and location Open Access

Gareth R Howell; Pete Williams; Jeffrey Harder; James Tribble; Keating Pepper; Stephen Cross; Paul Morgan; James Edwards Morgan; Simon W John

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Soluble Fas ligand provides long-term protection in a chronic mouse model of glaucoma by inhibiting glial activation, inflammation, and apoptosis Open Access

Meredith S Gregory-Ksander; Fei Fei; Ann Marshak-Rothstein; Bruce Ksander; Anitha Krishnan

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Müller glial cell-specific GDNF expression promotes retinal ganglion cell survival in DBA/2J mice Open Access

Anna M Demetriades; Chendong Pan; Leah C Byrne; Erum Ahmed; Jeffrey Harder; Simon W John; John Gerard Flannery

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Improved neuronal survival after intravitreal injection of an α-synuclein antibody in a glaucoma animal model Open Access

Julia Teister; Fabian Anders; Verena Prokosch; Sabine Beck; Sebastian Funke; Caroline Manicam; Adrian Gericke; Norbert Pfeiffer; Franz H Grus

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ocular hypertension induces early mitochondrial alterations in retinal endothelial cells in a murine glaucoma model Open Access

Yoko Ito; Ariel Wilson; Christine Vande Velde; Przemyslaw Mike Sapieha; Adriana Di Polo

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Adaptive Optics Scanning Light Ophthalmoscopy Microangiography Open Access

Richard B Rosen

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Understanding of inflammatory and non-inflammatory choroidal thickening using laser speckle flowgraphy Open Access

Susumu Ishida

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

En Face OCT Measurement of the Ocular Circulation Open Access

David Huang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

OCTA - overview of the technology and outlook for the future Open Access

James G Fujimoto

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Quantitative flow assessments with OCT Angiography Open Access

Johannes F De Boer

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Noninvasive visualization and analysis of the human parafoveal capillary network using swept source OCT optical microangiography Open Access

Srinivas R Sadda

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

OCTA in retinal vascular diseases Open Access

Nadia K Waheed

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Imaging Choroidal Neovascularization with OCTA Open Access

David Sarraf

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

OCTA in atrophic maculopathies Open Access

Giovanni Staurenghi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Corneal Sub-Basal Nerve Plexus Density in Parkinson’s Disease Open Access

Hannah Kersten; Stuti Misra; Richard H Roxburgh; Helen V Danesh-Meyer; Charles NJ McGhee

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Reversibility of diet-induced corneal degeneration in a mouse model Open Access

Aubrey Hargrave; Madhavi Chintalapati; Pooja Mehta; Paul Landry; Sri Magadi; Clifton Wayne Smith; Alan Robert Burns

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Relationships between central corneal nerve parameters and tear neuropeptides
Open Access

Fiona Stapleton; Cecilia Chao; Isabelle Jalbert; Preeji Sudharman Mandathara; Sailesh Kolanu; Mark D P Willcox; Maria Markoulli; Jingjing You; Juno Kim; Edward Lum; Blanka Golebiowski

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Pathological lymphangiogenesis is regulated by galectin-8-dependent crosstalk among VEGF-C, podoplanin and integrin pathways Open Access

Wei-Sheng Chen; Zhiyi Cao; Satoshi Sugaya; Maria Jose Lopez; Victor Sendra; Nora V Laver; Pedram Hamrah; Noorjahan A Panjwani

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Cholinergic regulation of dendritic cell uptake and immune response to topically applied antigens to the conjunctiva Open Access

Stephen C Pflugfelder; Cintia S De Paiva; Terry G Coursey; Flavia L Barbosa

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The ocular surface phenotype of Spdef -/- mice: Accumulation of debris but lack of infection upon challenge with Pseudomonas aeruginosa Open Access

Ilene K Gipson; Sandra Spurr-Michaud; Ann Tisdale; Balaraj Balaram Menon

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Aging, age-related macular degeneration, and the neural economy hypothesis Open Access

Ann E Elsner; Joel A Papay; Kirby D. Johnston; Brett King; Samantha L. Polster; Toco Yuen Ping Chui; Stephen A Burns

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Modeling the Relationship Between Foveal Cone Density and Outer Segment Length Open Access

Melissa A Wilk; Robert F Cooper; Brandon M Wilk; Christopher S Langlo; Joseph Carroll

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Imaging Photoreceptor Shedding in the Living Human Eye Open Access

Omer Pars Kocaoglu; Zhuolin Liu; Kazuhiro Kurokawa; Donald Thomas Miller

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Individual inner retinal neurons imaged in the living eye of monkey and human Open Access

Ethan A Rossi; Robin Sharma; Charles Granger; Christina Schwarz; Qiang Yang; Jennifer J Hunter; David R Williams

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Measuring organelle motility in RPE cells in the living human retina Open Access

Zhuolin Liu; Kazuhiro Kurokawa; Omer Pars Kocaoglu; Furu Zhang; Donald Thomas Miller

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

New evidence suggesting that the central endothelium presents features of peripheral endothelium in Fuchs endothelial corneal dystrophy Open Access

Zhiguo HE; Philippe GAIN; Albert S Jun; Fabien Forest; Laura KALLAY; Jean Marc Dumollard; Florian BERGANDI; Michel PEOC’H; Gilles Thuret

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Trinucleotide repeat expansion and TCF4 gene expression in Fuchs endothelial corneal dystrophy Open Access

Keisuke Ogata; Naoki Okumura; Ryosuke Hayashi; Makiko Nakahara; Masakazu Nakano; Kei Tashiro; Shigeru Kinoshita; Ursula Schlötzer-Schrehardt; Theofilos Tourtas; Friedrich E Kruse; Noriko Koizumi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

UV-A Irradiation Induced Mouse Model of Fuchs Endothelial Corneal Dystrophy Open Access

Cailing Liu; Takashi Miyai; Dijana Vojnovic; Irene E Kochevar; Ula V Jurkunas

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Unfolded protein accumulation induced endoplasmic reticulum stress of corneal endothelial cells in Fuchs endothelial corneal dystrophy Open Access

Naoki Okumura; Keisuke Hashimoto; Miu Kitahara; Makiko Nakahara; Shigeru Kinoshita; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Noriko Koizumi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Regulation of mitochondrial respiration under cell culture stress in human corneal endothelial cells Open Access

Shigeru Kinoshita; Morio Ueno; Kazuko Asada; Munetoyo Toda; Kazue Nagata; Chie Sotozono; Nobuyoshi Kosaka; Takahiro Ochiya; Junji Hamuro

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Functional gene transfer for antiapoptotic therapy of corneal endothelial cells – a magnetofection approach. Open Access

Marta Czugala; Olga Mykhaylyk; Anja Katharina Gruenert; Friedrich E Kruse; Sebastian Wesselborg; Christian Plank; Thomas Armin Fuchsluger

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Corneal Endothelial Pump Is Dependent on Buffering Lactic Acid Efflux Open Access

Joseph A Bonanno; Edward Kim; Shimin Li

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Endogenous expression of mutant BEST1 results in decreased Cl^- and Ca²⁺ conductance in human retinal pigment epithelium. Open Access

Michael D O'Connor; Melissa Mangala; Morven Cameron; John Morley

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Human embryonic stem cell-derived retinal pigment epithelial cells functionally integrate and rescue photoreceptors in a large-eyed model of geographic atrophy Open Access

Sandra Petrus-Reurer; Alvaro Plaza Reyes; Liselotte Antonsson; Sonya Stenfelt; Hammurabi Bartuma; Sarita Panula; Helder Andre; Outi Hovatta; Fredrik Lanner; Anders P Kvanta

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Exogenous factors induce rod and cone photoreceptor-specific progenitors from adult mouse retinal stem cells Open Access

Brian G Ballios; Saeed Khalili; Kenneth Grise; Laura Donaldson; Gilbert Bernier; Molly Shoichet; Valerie Wallace; Derek van der Kooy

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Patient-specific iPSCs to investigate pathophysiology and develop treatments for RPGR-associated XLRP Open Access

Joseph C Giacalone; Erin R Burnight; Tasneem P Sharma; Luke A Wiley; Dalyz Ochoa; Malia Collins; Robert F Mullins; Budd A Tucker; Edwin M Stone

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The effect of human embryonic stem cell-derived extracellular vesicles (hESEVs) on Müller cells and their potential use for retinal regeneration
Open Access

Debora B Farber

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Teleophthalmology in a Community Setting to Improve Eye Health Among Latinos: A Paradigm Shift Open Access

Judy E Kim; Velinka Medic; Al Castro; Blanca Rodriguez; Militza Bonet; Melissa DeNomie; Zeno Franco; Veli Melih Bilen; Sally Cho; Sheikh Ahamed

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Increased Incidence of Glaucoma Diagnosis Following Passage of Medical Marijuana Legislation Open Access

David S Sanders; Joshua R Ehrlich; Taylor Blachley; Theresa Cooney; Joshua D Stein

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Study of Knowledge, Attitudes and Practices Related to Eye Diseases in the Southern Indian States of Andhra Pradesh and Telangana Open Access

Srinivasa Pallerla

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Surgical Simulation in Low-resource Settings Improves Intra-operative Aspects of Trichiasis Surgery Training Open Access

Emily W Gower; Amir Bedri Kello; Martin Kollmann; James Johnson

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Barriers to accessing surgery for trachomatis trichiasis in Kongwa, Tanzania Open Access

Ryan James Bickley; Harran Mkocha; Beatriz E Munoz; Sheila K West

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Quantification of the neurons in the rod pathway of human retina Open Access

Sammy Chi Sam Lee; Rhian Jessi Aghajani; Paul R Martin; Ulrike Grunert

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Cone photoreceptors generate inhibitory ON and OFF responses in dopamingergic amacrine cells via distinct OFF pathways Open Access

Sheng-Nan Qiao; Yong-Mei Zhong; Dao-Qi Zhang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Rod photoreceptors mediate light-evoked activity of dopaminergic amacrine cells across a wide range of light intensities Open Access

Xiwu Zhao; Sheng-Nan Qiao; Yong-Mei Zhong; Kwoon Y Wong; Dao-Qi Zhang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The absence of complexin 3 alters rod bipolar cell pathway function Open Access

Joshua H Singer; Lena S Mortensen; Silvia Jee Hyun Park; Jiang-bin Ke; Lei Zhang; Nils Brose; Jeong-Seop Rhee; Jonathan B Demb

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Calcium signaling at Cx36 gap junctions in the mouse retina Open Access

John O'Brien; Ya-Ping Lin; Wade Kothmann; Keith B Moore; Cheryl K Mitchell; Jeffrey S Diamond

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Connectomics of irradiance-encoding ON bipolar-cell inputs to ipRGCs Open Access

Shai Sabbah; Min Tae Kim; Gabrielle Manoff; Ananya Bhatia-Lin; Carin Papendorp; Kevin Briggman; David M Berson

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Postnatal development of rod bipolar cell dendrites in mouse retina Open Access

Ivan Anastassov; Felice Dunn

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Novel biomarkers of diabetic retinopathy based on dynamic fluorescein enhanced fluorescent imaging Open Access

Jennifer J Kang-Mieler; Emily Dosmar; Wenqiang Liu; Sahar Hu; Kenneth M Tichauer

Investigative Ophthalmology & Visual Science September 2016, Vol.57, 3286a. doi:

Longitudinal reproducibility of spectral domain optical coherence tomography (SD-OCT) in children with stable glaucoma and physiological cupping Open Access

Limin Xu; Mays El-Dairi; Evan Silverstein; Sharon Freedman

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Diagnostic Innovations in Glaucoma Study (DIGS): OCT Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects Open Access

Min Hee Suh; Linda M Zangwill; Akram Belghith; Adeleh Yarmohammadi; Patricia Isabel C Manalastas; Alberto Diniz-Filho; Naeem Fatehee; Siamak Yousefi; Robert N Weinreb

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Generation of retinal photoreceptors from cGMP-Manufactured Human IPSC line Open Access

Jie Zhu; Helen Cifuentes; Joseph Reynolds; Deepak A Lamba

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A novel biosynthetic RPE-BrM (Retinal Pigment Epithelium-Bruch's Membrane) assembly suitable for retinal transplantation therapy Open Access

Andrew J Lotery; Gareth Ward; Philip Alexander; David Johnston; Anton Page; Angela Jane Cree; Atul Bhaskar; Sumeet Mahajan; Martin Grossel; J Arjuna Ratnayaka

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Phase I/II clinical trial of human embryonic stem cell (hESC)-derived retinal pigmented epithelium (RPE) transplantation in Stargardt disease (STGD): One-year results Open Access

Manjit Singh Mehat

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Transplantation of Autologous induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets for Exudative Age Related Macular Degeneration : A Pilot Clinical Study

Open Access

Yasuo Kurimoto; Yasuhiko Hirami; Masashi Fujihara; Chikako Morinaga; Midori Yamamoto; Kanako Fujita; Sunao Sugita; Michiko Mandai; Masayo Takahashi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Peripheral Retinal Abnormalities Associated with Age-Related Macular Degeneration in the Age-Related Eye Diseases Study 2 (AREDS2) Open Access

Thomas R Friberg; Amitha Domalpally; Ron Danis; Traci E Clemons; Srinivas R Sadda; Cynthia A Toth; Emily Y Chew

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Histological stages of subretinal drusenoid deposits (SDD) in eyes with age-related macular degeneration (AMD) Open Access

Christine A Curcio; Jeffrey D Messinger; Yuhua Zhang; David Neely; K Bailey Freund; Richard F Spaide

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Fully Automated Identification of Lesion Activity in Neovascular AMD Open Access

Anat Loewenstein; Dafna Goldenberg; Usha Chakravarthy; Graham Young; Moshe Havilio; Omer Rafaeli; Gidi Benyamini

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Automated identification and quantification of subretinal fibrosis in neovascular age-related macular degeneration using polarization-sensitive optical coherence tomography Open Access

Philipp Ken Roberts; Mitsuro Sugita; Gabor Dèak; Bernhard Baumann; Stefan Zotter; Michael Pircher; Stefan Sacu; Christoph K Hitzenberger; Ursula Schmidt-Erfurth

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Limbal Stem Cells Activate Autophagy to Recruit Ocular Master Regulator PAX6 in Cellular Stress Response to Ultraviolet A Radiation Open Access

Maria Laggner; Andreas Pollreisz; Gerald Schmidinger; Ursula Schmidt-Erfurth; Ying-Ting Chen

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Autophagy, a protective factor in limbal epithelium, is positively regulated by a microRNA family Open Access

Han Peng; Jong Kook; Julia Katsnelson; Wending Yang; CongCong He; Robert M Lavker

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Screening apoptosis markers in human corneal endothelium and epithelium Open Access

Siddharth Mahajan; Daniel Thieme; Friedrich E Kruse; Thomas Armin Fuchsluger

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Loss of human corneal epithelial cell identity exhibited by deletion of PAX6 using the CRISPR/Cas9 system Open Access

Koji Kitazawa; Takafusa Hikichi; Takahiro Nakamura; Chie Sotozono; Shigeru Kinoshita; Shinji Masui

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Small Wnt Inhibitors Modulate the Expansion of Limbal Stem/Progenitor Cells in vitro Open Access

Hua Mei; Chi Zhang; Elfren Ray Baclagon; Jie J Zheng; Sophie Xiaohui Deng

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ascorbic acid, and not L-DOPA, protects against form-deprivation myopia in retinal degeneration mouse models. Open Access

Erica Landis; Hanna Park; Ranjay Chakraborty; Curran Sidhu; P. Michael Iuvone; Machelle T Pardue

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Intrinsic Ocular Mechanisms Underlie Lens-Induced Astigmatism in Chicks Open Access

William K Stell; Vanessa Popa; Chea-Su Kee

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Origin of different responses to myopia-inducing stimuli in two guinea pig strains Open Access

Liqin Jiang; Sarah Kochik; Yang Shen; Christine Frances Wildsoet

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Visually Regulated Gene Expression of Apolipoprotein A-1 in Chick Eyes Open Access

Jody A Summers Rada; Angelica Harper; John Moore

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Non-visual factors influencing emmetropization in chicks Open Access

Xiaoying Zhu; Josh Wallman; Sally A McFadden

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Beta1 integrin is a negative regulator of lens epithelial to fiber cell differentiation in the early lens Open Access

Melinda K Duncan; Mallika Pathania; Yan Wang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A Critical Role for N-cadherin in Lens Fiber Cell Migration along the EFI for Lens Morphogenesis Open Access

Caitlin Logan; Suren Rajakaruna; Glenn Radice; Michael L Robinson; A Sue Menko

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Analysis of FGFR2 Regulated Transcripts in the Newborn Mouse Lens Open Access

Michael L Robinson; Stephanie L. Padula; Thanh Hoang; Lin Liu; Chun Liang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The molecular basis of crystallin gene expresssion in lens: Role of FGF signaling and c-MAF Open Access

Ales Cvekl; Qing Xie; Rebecca McGreal; Raven Harris; Saima Limi; Chun Gao; Wei Liu; Lixing W Reneker; Linda Musil

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Gene Expression in Single Fiber Cells of the Ocular Lens: A window into molecular heterogeneity in a functional tissue Open Access

Suraj P Bhat; Rajendra K Gangalum; Dennis Mock

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Lens differentiation rides the wave of p27^Kip1 to lens fiber cell denucleation Open Access

Allen Taylor; Sheldon Rowan; Min-Lee Chang; Fu Shang; Natalie Reznikov; Lei Lyu; Ke Liu

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Characterization of Lens Fiber Cell Membrane Microdomains by Proteomics Analysis of Lipid Rafts Open Access

Vasanth Rao; Rasiah Pratheepa kumari; Nikolai Skiba

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Dominant role of arachidonic acid pathways in light-activated rod-induced neurovascular response accessed by retinal optical imaging Open Access

Daniel Y Tso; Momotaz Begum

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Magnification Characteristics on Optical Coherence Tomography Systems Open Access

Dirk-Uwe G Bartsch

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Through-focus binocular contrast sensitivity of monofocal and multifocal intraocular lens predicted by an adaptive optics visual simulator Open Access

Aixa Alarcon; Carmen Canovas; Silvestre Manzanera; Pedro Prieto; Kendra Hileman; Patricia A Piers; Pablo Artal

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Stereoscopic acuity as a function of induced monocular defocus measured with an adaptive optics simulator Open Access

Silvestre Manzanera; Aixa Alarcon; Carmen Canovas; Pedro Prieto; Adrian Gambin; Henk A Weeber; Patricia A Piers; Pablo Artal

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Neural Binocular Summation Altered by Abnormal Interocular Disparities in Normally Developed Visual Systems Open Access

Robert Dowd; Antoine Barbot; Geunyoung Yoon; Krystel R Huxlin; Duje Tadin

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Investigation of the two types of cellular connections of Schlemm's canal inner wall cells and their role in giant vacuole and pore formation by serial block-face scanning electron micros... Open Access

Julia Lai; Dimitr Getchevski; Athan Zavras; Davy Huang; Syian Srikumar; Haiyan Gong

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Crosstalk between TGFβ2 and TLR4 in the trabecular meshwork Open Access

Colleen M McDowell; Humberto Hernandez; Abbot F Clark

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A role for exosomes in steroid induced ECM accumulation in the TM Open Access

W. Michael Dismuke; W Daniel Stamer

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The role of VEGF on outflow facility in mice with glucocorticoid-induced ocular hypertension Open Access

Ester Reina-Torres; Joseph M. Sherwood; Darryl R. Overby

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The Role of Growth Differentiation Factor-15 in Regulation of Contractile Properties of Human Trabecular Meshwork Cells Open Access

Arumugam Ramachandran Muralidharan; Rupalatha Maddala; Vasanth Rao

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Human Adipose-derived Stem Cells Integrate into Normal Mouse Trabecular Meshwork Open Access

YI ZHOU; HONGMIN YUN; Enzhi Yang; Xiaobo Xia; Joel S Schuman; Yiqin Du

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

High heterogeneity in the receptive-field subunit maps of multiple nearby neurons in infant V2 Open Access

Bin Zhang; Xiaofeng Tao; Guofu Shen; Janice Marie Wensveen; Earl L Smith; Yuzo M Chino

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Disconnection of ipsilateral FEF from the attention network in strabismic amblyopia during coherent motion task Open Access

Sheila Gillard Crewther; Hao Wang; Mingiong Liang; Tao Yu; Jian Wang; David P Crewther; Robin Laycock; Zheng Yin

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Binocular Interactions during Rapid Alternating Occlusion as measured with Visual Evoked Potentials Open Access

Hilary Ann Hamer; Andrew McLeod; Athanasios Panorgias

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Home use binocular dichoptic video content treatment for amblyopia-pilot study Open Access

chaim Stolovitch

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Greater eye movement disconjugacy with near fixation in amblyopia during binocular viewing is associated with increased microsaccade rate Open Access

Howard S Ying; Soolienah Rhiu; Connie Yang; Vivian Xu; Robert Geary; Boris I Gramatikov; David L Guyton; Kristina Irsch

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Disinvestment of population-wide eye screening at age 6-24 months in the Netherlands Open Access

Frea Sloot; Hatice Karaman; Aya Sami; Sjoukje E Loudon; Janine Benjamins; Huibert Jan Simonsz

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Detection of Amblyopia in Young Children via Retinal Rivalry Using a Video Game Styled Interface on a Tablet Device Open Access

Ryan Gise; Steven Kane

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Thrombospondin-derived peptide attenuates Sjögren’s syndrome-associated ocular surface inflammation Open Access

Laura Contreras-Ruiz; Fayaz A Mir; Bruce Turpie; Sharmila Masli

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Identifying the mechanism of NF-kB activation by Toxoplasma gondii’s strain II dense granule GRA15 (GRA15 (II)) Open Access

Eleni Konstantinou; Ninghan Yang; Jeroen P.J. Saeij; Lucy H. Young

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Contrary effects of Interleukin-1 receptor antagonist (Ra) and IL-36Ra on corneal innate immune defense against Pseudomonas aeruginosa keratitis. Open Access

Nan Gao; Fushin X Yu; Theodore J. Standiford

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

TLR2 and ALX/FPR2 receptor “cross talk” is essential for Resolvin D1 (RvD1)-mediated inflammation resolution and protection in Staphylococcus aureus endophthalmitis. Open Access

Pawan Kumar Singh; Ajay Kumar; Ashok Kumar

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A Novel Pollen/TLR4 Concept, an Innate Immunity Signaling Initiating IL-33/ST2 Pathways in Th2-dominant Allergic Inflammation Open Access

De-Quan Li; JIN LI; Lili Zhang; Xin Chen; Stephen C Pflugfelder; Xia Hua; Fang Bian

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Laminin β2 Chain Regulates Retinal Progenitor Cell Mitotic Spindle Orientation Open Access

Dmitri Serjanov; galina bachay; Dale D Hunter; William J Brunken

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Tet2 and Tet3 methylcytosine dioxygenases are required for retinal neurogenesis during zebrafish eye development Open Access

Jeffrey M Gross; Pawat Seritrakul

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The microRNA miR-18a regulates NeuroD and photoreceptor differentiation Open Access

Scott M Taylor; Peter F Hitchcock

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Type 4 cone bipolar cell dendrite morphology is maintained by DSCAM and BAX in the adult mouse retina. Open Access

Aaron B Simmons; Samuel Bloomsburg; Deidrie Briggs; Josh Hix; Emmalee Pecor; Samuel Billingslea; Jaime Young; Peter G Fuerst

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ccnd1-Cdk4 stimulates Müller glia cell cycle re-entry in the mouse retina Open Access

Sheik Pran Babu Sardar Pasha; Federico Calegari; Mike.O Karl

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Reelin and Synaptic Genes are Enriched in GCL Transcriptome during Early Inner Plexiform Layer Development Open Access

Steve The Luan Huynh; David M Sherry; Preethi Gunaratne; Deborah C Otteson

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The role of Satb2 in establishing Direction-Selective Retinal Ganglion Cell identity in the mouse retina Open Access

Andreea Nistorica; Neal Sweeney; David Feldheim

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Twelve years incidence of open-angle glaucoma in the Thessaloniki Eye Study Open Access

Fotis Topouzis; M Roy Wilson; Alon Harris; Panayiota Founti; Fei Yu; Theofanis Pappas; Eleftherios Anastasopoulos; Angeliki Salonikiou; Vassilis Kilintzis; Anne L Coleman

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Sex hormone levels and risk of primary open-angle glaucoma in postmenopausal women Open Access

Jae H Kang; Janey L Wiggs; Louis R Pasquale

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Evaluation of activity-normalized fall rates in glaucoma Open Access

Pradeep Y Ramulu; Aleksandra Mihailovic; Sheila K West; David S Friedman

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Association between Glaucoma Progression and Medication Adherence: 7-Year Study of Veterans Affairs Maryland Health Care System Database Open Access

Eva DeVience; Stephen DeVience; Katherine Williams; Michael V Boland; Lily Im; Rex Ballinger; David S Friedman; Osamah Saeedi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Cost-utility analysis of cataract extraction by phacoemulsification versus combined phacotrabeculectomy in treating chronic angle closure glaucoma (CACG) with coexisting cataract Open Access

Xiaofei MAN

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Driving Performance in Subjects with Glaucomatous Visual Field Loss as Investigated in a Driving Simulator Open Access

Amir Marvasti; Alberto Diniz-Filho; Erwin R Boer; Peter Rosen; Felipe A Medeiros

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

ARL2BP is essential for the function of rod and cone photoreceptor cells Open Access

Abigail Ruth Hayes; Ratnesh Singh; Visvanathan Ramamurthy

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Trafficking of transducin-α by UNC119A/B and ARL3^GTP dependent diffusion Open Access

Wolfgang Baehr; Cecilia D gerstner; Christin Hanke-Gogokhia; Guoxin ying; Jeanne M Frederick

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The Role of Circadian Rhythms in Regulating the Cone Phototransduction Cascade Shutoff in Zebrafish Retina Open Access

Stephan C F Neuhauss; Jennifer Keim; Jingjing Zang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Posttranslational Lipid Modification Controls the Trafficking of Transducin to the Photoreceptor Cilium Open Access

Maxim Sokolov; Marycharmain Belcastro; Joseph Murphy; Saravanan Kolandaivelu

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ablation of Retbindin Alters Flavin Levels and Leads to Rod and Cone Photoreceptor Degeneration Open Access

Muayyad R Al-Ubaidi; Ryan Kelley; Jianhai Du; James Hurley; Muna I Naash

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Design, generation, and initial characterization of gene-edited mice for the analysis of the peripherin-2/rds (P/rds) cytoplasmic C-terminal domain. Open Access

Andrew F X Goldberg; Breyanna Cavanaugh; Michelle L Milstein; Victoria A Kimler; Kenneth P Mitton; Thomas Saunders

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Long-term treatment with 9-cis-β-carotene rich alga Dunaliella Bardawil inhibits photoreceptor degeneration in a mouse model of retinoid cycle defect Open Access

Ifat Sher; Victoria Edelshtain; Adi Tzameret; Dror Harats; Aviv Shaish; Ygal Rotenstreich

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

What the mouse eye tells the mouse's brain: a functional classification of retinal ganglion cells Open Access

Tom Baden

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Multiple synaptic mechanisms underlying direction selectivity in the mouse retina Open Access

Wei Wei

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

New roles for intrinsically photosensitive retinal ganglion cells Open Access

Tiffany Schmidt

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Direction Selectivity in the Mouse Superior Colliculus Open Access

Jianhua Cang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Visual processing in the mouse thalamocortical pathway Open Access

Cristopher Niell

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ocular hypotensive effects and tolerability of the novel dual EP3/FP receptor agonist ONO-9054 vs. Xalatan®: Results of a 28 day, double masked, randomized, active comparator study in ope... Open Access

Eydie G Miller-Ellis; Michael S. Berlin; Caroline L Ward; John Sharpe; Alam Jamil; Alon Harris

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Two Phase 3 studies of the efficacy and safety of AR-13324 Ophthalmic Solution 0.02%: in Patients with Open Angle Glaucoma and Ocular Hypertension Open Access

L Jay Katz; Mark J. Weiss; Theresa Heah; Casey Kopczynski; Gary D Novack

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Effect of Yoga and Meditation Based Intervention on Intraocular Pressure, Quality of Life, Oxidative Stress and Gene Expression Pattern in Primary Open Angle Glaucoma: A Randomized Contro... Open Access

Tanuj Dada; Muneeb A. Faiq; Kuldeep Mohanty; Deepti Mittal; Muzaffer Bhat; Raj Kumar Yadav; Ramanjit Sihota; Rima Dada; Ravindra M Pandey

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Repeat selective laser trabeculoplasty in Afro-Caribbean eyes with primary open-angle glaucoma Open Access

Tony Realini; Hilda Curtis

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The Singapore Asymptomatic Narrow Angles Laser Iridotomy Study (ANA-LIS): 5-year results Open Access

Baskaran Mani; Rajesh Sasikumar; Hon Tym Wong; Paul Chew; Paul J Foster; David S Friedman; Tin Aung

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Are patient self-reported outcome measures (PROMs) sensitive enough to be used as endpoints in clinical trials? Evidence from the UK Glaucoma Treatment Study. Open Access

Lee Jones; David F Garway-Heath; David Crabb

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Six-month-change in microperimetric mean sensitivity, fixation location and fixation stability in Stargardt disease: The prospective ProgStar study Open Access

Shazia Khan; Xiangrong Kong; Rupert Wolfgang Strauss; Mohamed A Ibrahim; Etienne M. Schonbach; Saddek Mohand-Said; Michel Michaelides; David G Birch; Janet S Sunness; Srinivas R Sadda; Hendrik P Scholl

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Progression of atrophic lesions prospectively determined by fundus autofluorescence: the natural history of the progression of atrophy secondary to Stargardt disease (ProgStar) study Open Access

Rupert Wolfgang Strauss; Xiangrong Kong; Anamika Jha; Paul S Bernstein; Michel Michaelides; Jose Sahel; Elias I Traboulsi; Eberhart Zrenner; Sheila K West; Srinivas R Sadda; Hendrik P Scholl

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Visual acuity loss during one year in Stargardt Disease: ProgStar Prospective Study Open Access

Xiangrong Kong; Rupert Wolfgang Strauss; Ann-Margret Ervin; Paul S Bernstein; Artur V Cideciyan; Janet S Sunness; Elias I Traboulsi; Beatriz E Munoz; Mohamed Ahmed; Sheila K West; Hendrik P Scholl

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Clinical evaluation of an intensively genotyped cohort of macular and cone/cone-rod dystrophy patients
Open Access

Johannes Birtel; Philipp L. Mueller; Martin Gliem; Elisabeth Mangold; Frank G Holz; Christine Neuhaus; Hanno Joern Bolz; Peter Charbel Issa

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

RPE degeneration precedes photoreceptor and choroidal loss in choroideremia based on enhanced-depth OCT and fundus autofluorescence correlations Open Access

Kanmin Xue; Marta Oldani; Jasleen Jolly; Thomas L Edwards; Robert Maclaren

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Characteristics of 3’ORF15 mutations in RPGR Open Access

Kari E Branham; Naheed W Khan; Dana Schlegel; Kanishka Thiran Jayasundera; John R Heckenlively

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Long Term Risk for Geographic Atrophy in Correlation to Choroidal Thickness in Patients Receiving a Treat-and-Extend Regimen of Anti-Vascular Endothelial Growth Factor Agents Open Access

Elona Gavazi; Lekha Ravindraraj; Nicolas Alessandro Yannuzzi; Samir N Patel; Luna Xu; K Bailey Freund

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Are Systemic Levels of Amyloid β Altered in Patients with Geographic Atrophy? Open Access

Kameran Lashkari; Francisco J Lopez; Gianna C Teague; Sanjay Kumar; Megan M McLaughlin

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Progression of Geographic Atrophy in the Age-Related Eye Disease Study 2 (AREDS2) Open Access

Emily Y Chew; Elvira Agron; Traci E Clemons; Amitha Domalpally; Ronald P Danis

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Decreased Renal Function is Associated with Reticular Macular Disease (RMD) in Patients with Age-Related Macular Degeneration (AMD) Open Access

Heather Leisy; Meleha Ahmad; Michael Marmor; Theodore Smith

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Optical Quality and Visual Performance after Relex SMILE, LASIK or PRK Refractive Surgery Procedures for Myopia Open Access

Shrikant R Bharadwaj; Samrat Sarkar; Jagadesh Reddy; Pravin Krishna Vadavalli

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Effects of Small-Incision Lenticule Extraction (SMILE) on Corneal Endothelial Cells Open Access

Jesus Cabral; Flor Daniela Guzman-Iturbe; Alejandro Navas; Aida Jimenez-Corona; Enrique O Graue-Hernandez; Arturo J Ramirez-Miranda

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

In Vivo Confocal Microscopic Imaging of the Cornea After Autologous Lenticule Implantation Obtained by SMILE for Hyperopia Open Access

Meiyan Li; Xingtao Zhou; Ling Sun

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Safety and Efficacy of Myopic LASIK performed in Thin Corneas Open Access

Jorge E Valdez; Víctor Preciado-Gómez; Javier Gonzalez-Lugo; Julio C Hernandez-Camarena; Jesus Merayo-Lloves

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Visual Outcomes After Wavefront-Guided and Conventional Ablation Using the Visx Laser for LASIK Retreatment
Open Access

Zeba Syed; Kenneth A. Garrett; Jonathan Kruh; Brian Huntington; Steve Robinson; Samir Melki

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

UVAB and Cross Linking epi – off produce similar damage in hens cornea Open Access

Gisele Cristina Gonçalves de Almeida Cunha; Lucia ibares-Frias; Roberto Cantalapiedra; Patricia Gallego; María Carmen Martínez-García; Jesus Merayo-Lloves

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Evaluating the effect of corneal inlay implantation depth on visual outcomes and stability Open Access

Ling Lin; Srividhya Vilupuru; Jay Stuart Pepose

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Solution structure of human GammaC crystallin Open Access

Ajay Pande; Karuna Dixit; Siddhartha Sarma; Jayanti Pande

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Destabilized human γD-crystallins form aggregation in the zebrafish lens Open Access

Alexandra Fuller; Shu-Yu Wu; Sanjay Mishra; Ping Zou; Hassane S Mchaourab

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

UV-light- and oxidative stress-dependent phosphorylation and translocation of αB-crystallin to the mitochondria and nucleus of lens epithelial cells and its protection of lens organelles. Open Access

Lisa A Brennan; Rebecca McGreal; Daniel Chauss; Josef Khoury; Marc Kantorow

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Identification of novel amino acid modifications in human lens proteins: mechanisms and relevance. Open Access

Stefan Rakete; Ram H Nagaraj

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Quantification of crystallin deamidation in aged human lenses by high-resolution mass spectrometry and data-independent fragment ion acquisition Open Access

Larry L. David; Jocelyn F Krey; Chaochao Wu; Eileen Yue; Phillip Wilmarth; Kirsten J Lampi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ascorbic acid oxidation contributes to methylglyoxal-derived hydroimidazolone formation in aged lens Open Access

Xingjun Fan; Benlian Wang; David Sell; Daniel Wesson; Vincent M Monnier

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Age-related Asp Isomerizations in Dissociated Alpha-crystallin from Aged Lens Open Access

Takumi Takata; Takashi Sato; Noriko Fujii

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Sex-related Differences in Ocular Immunitiy Open Access

Erich Knop

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Gender in ocular blood flow Open Access

Leopold Schmetterer

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Gender differences in ARMD Open Access

Francesco Bandello

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ethnic and gender differences on glaucoma risk. Open Access

Stefano A Gandolfi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Race and sex differences in sickle cells retinopathy Open Access

Caterina Gagliano

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Sex/Gender Disparities and Diabetic Retinopathy
Open Access

Andrew T C Tsin

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Gender and race differences in IOP and aqueous humor dynamics Open Access

Carol B Toris

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Macular polarimetric ophthalmoscopy Open Access

Joel A Papay

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

PS-OCT – enhanced contrast for ophthalmic imaging Open Access

Bernhard Baumann

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Fiber-based Jones-matrix polarization-sensitive OCT of the human retina Open Access

Boy Braaf

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Polarization sensitive OCT: Clinical application Open Access

Yasushi Ikuno

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Heparanase is a Host-Encoded Virulence Factor for Herpes Simplex Virus Ocular Infection Open Access

Deepak Shukla; Alex Agelidis; Satvik Hadigal

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Humoral immunity is requisite for vaccine-mediated protection against ocular HSV-1 infection Open Access

Derek J Royer; Hem Raj Gurung; Jeremy K. Jinkins; William Halford; Daniel J Carr

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Transparent and Self-defensive Polyvinyl Alcohol Films Open Access

Chetna Dhand; Seeram Ramakrishna; Roger W. Beuerman; Lakshminarayanan Rajamani

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Disruption of outer blood retinal barrier by Toxoplasma gondii-infected monocytes is mediated via FAK signaling pathway Open Access

Hyun Beom Song; Hyoung Oh Jun; Jin Hyoung Kim; Sang-Mok Lee; Jiwon Shim; Min-Ho Choi; Jeong Hun Kim

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Establishment of a new comprehensive polymerase chain reaction (PCR) strip kit to diagnose infectious eye diseases Open Access

Satoko Nakano; Sunao Sugita; Yasuhiro Tomaru; Takako Nakamuro; Hiroshi Takase; Norio Shimizu; Manabu Mochizuki; Toshiaki Kubota

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The Role Of Connexin 43 And PKCδ In The Phagocytosis Of Photoreceptor Outer Segments Open Access

korina theodoraki; Katharina Lueck; Morgane Gourlaouen; Apostolos Georgiannakis; Stephen E Moss

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Bestrophinopathy is an RPE-photoreceptor interface disease Open Access

Karina E Guziewicz; William A Beltran; Simone Iwabe; Artur V Cideciyan; Samuel G Jacobson; Anuradha Dhingra; Kathleen Battaglia; Gustavo D Aguirre

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Photoreceptor outer segments (POS) induce Retinal pigment epithelial (RPE) cell multinucleation through modulating the Protein Kinase C pathway Open Access

Dinusha Rajapakse; Mei Chen; Tim Curtis; Heping Xu

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Dopamine 2 Receptor Signaling Controls the Daily Burst in Phagocytic Activity by the Retinal Pigment Epithelium. Open Access

Gianluca Tosini; Kenkichi Baba; virginie Laurent; David Hicks

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Loss of ATG5 in the RPE slows phagosome degradation contributing to altered intracellular lipid processing. Open Access

Kathleen Boesze-Battaglia; Anuradha Dhingra; Desiree Alexander; Alvina Bragin; Daniel Lamond; Vanda Sofia Lopes; David Williams

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Retinal Pigment Epithelium (RPE) cells facing cone photoreceptors display distinct transciptome with implications for the pathogenesis of Age-related Macular Degeneration (AMD) Open Access

Shadi Safuri; Liat Bilgoray Brenner; Anat Loewenstein; Ido Perlman

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

ABCB5 identifies RPE progenitor cells required for normal retinal development and aging Open Access

Bruce Ksander; Andrew Hertsenberg; Ruth Y Lewis; Brian Wilson; Gretchen Berg; Markus Hermann Frank; Natasha Y Frank

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Functional Outcomes of the Low Vision Depression Prevention Trial (VITAL) in Age-Related Macular Degeneration Open Access

Ashley Deemer; Robert W Massof; Barry Rovner; Robin Casten

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Effectiveness and cost-effectiveness of portable electronic vision enhancement systems (p-EVES) compared to optical magnifiers for near vision activities in visual impairment Open Access

Chris Dickinson; Rachel Bambrick; Andrew Brand; Nathan Bray; Michelle Dutton; Robert Harper; Barbara Ryan; John J Taylor; Rhiannon Tudor Edwards; Heather Waterman

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The preferred retinal locus used to watch videos Open Access

Francisco Manuel Costela; Sidika Kajtezovic; Russell L Woods

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Gait parameters associated with fall risk in glaucoma patients Open Access

Aleksandra Mihailovic; David S Friedman; Sheila K West; Pradeep Y Ramulu

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Does Loss of Vision Impact a Pedestrian's Ability to Estimate their Own Street Crossing Time? Open Access

Shirin E Hassan

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

NEI audactious goals update Open Access

Paul A Sieving

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Optical Coherence Tomography (OCT) Demonstrates Deformation of Optic Cup and Peripapillary Tissues By Horizontal Duction Open Access

Melinda Chang; Andrew Shin; Joseph Park; Aaron Nagiel; Robert Lalane; Steven D Schwartz; Joseph L Demer

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma Open Access

Feilin Zhu; Alberto Diniz-Filho; Robert N Weinreb; Linda M Zangwill; Felipe A Medeiros

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Oral mineralocorticoid-receptor antagonists: real-life experience in clinical subtypes of non-resolving central serous chorioretinopathy with chronic epitheliopathy Open Access

Alexandre Matet; Alejandra Daruich; Ali Dirani; Mathilde Gallice; Luke Nicholson; Sobha Sivaprasad; Francine Behar-Cohen

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Inhibition of Choroidal Neovascularization in Rap1b^-/- Mice by Self complimentary-AAV2-delivered Constitutively Active Rap1a in Retinal Pigment Epithelium
Open Access

Haibo Wang; Xiaokun Han; Sadiki Deane; Colin A Bretz; Silke Becker; Angelina Jingtong Liu; Kevin Yang; M Elizabeth Hartnett

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Phase I Safety and Tolerability results for RetinoStat^®, a Lentiviral Vector Expressing Endostatin and Angiostatin, in Patients with Advanced Neovascular Age-Related Macular Degeneration Open Access

Andreas K Lauer; Peter A Campochiaro; Elliott H Sohn; Michelle Kelleher; Richard Harrop; Julie Loader; Scott Ellis; Kyriacos Mitrophanous

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A combined phase 2a/b study of the efficacy, safety, and tolerability of repeated topical doses of regorafenib eye drops in treatment-naïve patients with neovascular age-related macular d... Open Access

Antonia M Joussen; Sebastian Wolf; Peter K Kaiser; David S Boyer; Thomas Schmelter; Rupert Sandbrink; Oliver Zeitz; Michael K Boettger; Brigitte Stemper

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Prospective, Multicenter Investigation of Aflibercept Treat and Extend Therapy for Neovascular Age-related Macular Degeneration (ATLAS Study): One and Two Year Results Open Access

Francis Char DeCroos; David Carleton Reed; Murtaza K Adam; David A Salz; Omesh Gupta; Allen C Ho; Carl D Regillo

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Developing Autologous Cell Therapy for Age-related Macular Degeneration using Patient-specific Induced Pluripotent Stem Cell derived Retinal Pigment Epithelium Open Access

Kapil Bharti; Vladimir Khristov; Balendu Jha; Maria Mercedes Campos; Zhu Raymond; Yichao Li; Haohua Qian; Arvydas Maminishkis; Steve T Charles; Juan Amaral; Sheldon S Miller

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Quality metrics and retinal detachment surgery: Time to unplanned return to the operating room Open Access

Alexander Grosinger; Benjamin Nicholson; Jose Pulido; Andrew Barkmeier; Raymond Iezzi; Sophie J Bakri

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Smoking is a risk factor for proliferative vitreoretinopathy after traumatic retinal detachment Open Access

Tomasz Stryjewski; Michael Andreoli; Christopher Andreoli; Dean Eliott

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Optical Coherence Tomography Angiography quantifying choroidal blood flow change of Idiopathic Macular Hole before and after surgery Open Access

Yufei Teng; Wu Liu

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Characterization of Mitochondrial and Metabolic Changes Following Retinal Detachment Open Access

Daniel Diaz-Aguilar; Zhaohui Li; Yoko Okunuki; arogya Khadka; Sarah Melissa P. Jacobo; Kip M Connor; Magali Saint-Geniez

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Ocular surface CD207+ cells prevent inflammatory cell infiltration and cytokine induction in dry eye mouse Open Access

Eunyoung Choi; Hyungoo Kang; Wungrak Choi; Inhee Moon; Areum Yeo; Hyemi Noh; Eung Kweon Kim; Hyeon Chang Kim; Hyung Keun Lee

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Allogeneic sensitization and tolerance induction post corneal endothelial cell injection into the anterior chamber Open Access

Jun Yamada; Morio Ueno; Munetoyo Toda; Katsuhiko Shinomiya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

An in vitro model to study antigen-induced macrophage activation and cytokine production in corneal allograft rejection Open Access

Paola Kammrath Betancor; Antonia Hildebrand; Florian Emmerich; Thomas Reinhard; Daniel Boehringer; Gunther R Schlunck; Thabo Lapp

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Pathological Conversion of Regulatory T Cells Cause Disruption of Immune Privilege Open Access

Jing Hua; Takenori Inomata; William Stevenson; Tina Shiang; Yihe Chen; Jeffrey Bluestone; Reza Dana

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

THE EFFECT OF AGE AND CONTACT LENS WEAR ON CORNEAL LANGERHANS CELLS Open Access

Blanka Golebiowski; Kim Bui; Winnie Lam; Cecilia Chao; Kathryn Richdale; Fiona Stapleton

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Prosthetic replacement of the ocular surface ecosystem in pediatric patients with chronic ocular surface disease after Stevens-Johnson syndrome and toxic epidermal necrolysis Open Access

Hajirah N Saeed; Thanos D Papakostas; Hong-Gam Le; James Chodosh; Deborah S Jacobs

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Effectiveness study of atropine for progressive myopia in Europeans; Two year follow up Open Access

Jan Roelof Polling; Gentiana Martinaj; Astrid van der Schans; Ruben G.W. Kok; Willem Tideman; Caroline C W Klaver

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Alpha₂-Adrenergic Agonists Inhibit Form-Deprivation Myopia (FDM) in the Chick Open Access

Brittany Carr; William K Stell

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Characterization of a novel retinaldehyde dehydrogenase selective inhibitor
Open Access

Angelica Harper; Tim Mather; Anh Le; Anthony Burgett; Gennadiy P Moiseyev; John Moore; Jody A Summers Rada

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Pharmacological inhibition of nitric oxide increases myopia susceptibility in mice Open Access

Ranjay Chakraborty; Michael A. Bergen; Erica Landis; Duk Cheon Lee; P. Michael Iuvone; Machelle T Pardue

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Asymmetries in sensitivity and spatial summation in the Hill of Vision Open Access

Jack Phu; Sieu K Khuu; Michael Kalloniatis

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Altered pattern of 1^st and 2^nd order visual processing after mild traumatic brain injury in humans Open Access

Daniel P Spiegel; Alexandre Reynaud; Tatiana Ruiz; Maude Laguë-Beauvais; Robert Hess; Reza Farivar

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Visual acuity testing: feedback affects neither outcome nor reproducibility, but leaves participants happier Open Access

Michael Bach; Kerstin Schäfer

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Comparison of logMAR, random logMAR and a Predictive Threshold Acuity test Open Access

Stefania Giulvezan; Kevin Gallagher; Nigel Davies

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Development and Testing of an Automated Computer Tablet-Based Method for Self-Testing of High and Low contrast Near Visual Acuity in Ophthalmic Patients. Open Access

Humza Tahir; Ian J Murray; Neil Robert Alan Parry; Naznin Mirza; Tariq Aslam

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Wound repair is regulated by the gap junction protein connexin43 Open Access

Paul Lampe

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Connexin 43 in corneal and retinal injury and disease Open Access

Colin Green

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Neuronal Gap Junctions form Novel Therapeutic Targets for Neuroprotection in Glaucoma Open Access

Stewart A Bloomfield

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Regulation of Gap Junctional Coupling between Photoreceptors Open Access

Christophe P. Ribelayga

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Differences in second messenger permeability of lens connexins Open Access

Thomas William White

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Gap junctions provide metabolic coupling and adhesive niches for the morphogenesis of lens fibers Open Access

Xiaohua Gong

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Agreement among Uveitis Experts on Diagnosis: The SUN Classification Criteria Project Experience Open Access

Douglas A. Jabs

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Single Nucleotide Polymorphism in L23R-IL12RB2 gene is highly associated with Behcet's uveitis. Open Access

Michal Kramer; Murat Hasanreisoglu; Shirel Weiss; Deniz Kumova; Michal Schaap-Fogler; Sezen Ergun-Guntekin; Yair Molad; Nitza Goldenberg-Cohen; Yoram Cohen

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Sarcoidosis Related Uveitis: the Interplay Between Ocular and Systemic Disease Open Access

Shirley P Ma; Lauren Hodgson; Jessica Brennan; Anthony Hall; Richard Stawell; Lyndell L Lim

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Collaborative Ocular Tuberculosis Study (COTS) - A global multicentre study of clinical features and factors affecting treatment outcome in intraocular tuberculosis – report 1 Open Access

Dinesh Visva Gunasekeran; Vishali S Gupta; Carlos Pavesio; Robert Grant; Rupesh Vijay Agrawal

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

NEURO-OPHTHALMOLOGICAL MANIFESTATIONS OF BEHCET’S DISEASE. Open Access

Ammr Alghamdi; Bahram Bodaghi; bertrand wechsler; patrice cacoub; Phuc LeHoang; David Saadoun; Valérie Touitou

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Expanding the spectrum of Ebola-associated eye disease: a summary of ocular findings in a large cohort of Ebola survivors Open Access

Rachel Jessica Bishop; Allen O Eghrari; Christopher Brady; Vincent Ray; Cavan S Reilly; Frederick Ferris; Denise Cunningham; Edward Guizie; Mosoka Fallah

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Dark-Rearing (DR) precludes the initiating event in OIR and eliminates the pathology seen in the second phase of disease: Rationale for novel non-invasive treatment for ROP. Open Access

Tailoi Chan-Ling; Nigel L Barnett; Rita Maccarone; Jan Provis; Mark Koina; Ping Hu; Riccardo Natoli; Silvia Bisti; Robert A Linsenmeier; Samuel Adamson

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

TSPAN12 – a novel target for the treatment of vaso-proliferative retinopathy Open Access

Felicitas Bucher; Ding Zhang; Edith Aguilar; Jia Xie; Hongkai Zhang; Mauricio Rosenfeld; Sophia Aguilar; Richard Lerner; Kyungmoo Yea; Martin Friedlander

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Laminins, Containing g3 Chain, Regulate Vascular Remodeling and Arterial Identity Specification in the Retina Open Access

Saptarshi Biswas; Elizabeth Swallow; galina bachay; Dale D Hunter; William J Brunken

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Epoxydocosapentaenoic acid (EDP) and epoxyeicosatrienoic acid (EET) affect TNFα production and leukocyte adhesion in diabetic retinopathy Open Access

Megan E Capozzi; John S Penn

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Rescue of ECFCs by CD34⁺ cells via paracrine factors in a Mouse Model of Retinopathy of Prematurity (ROP)
Open Access

Sergio Li Calzi; Lynn C Shaw; William Christopher Shelley; Xiaoping Qi; Judith Quigley; Leni Moldovan; Snow Wu; Mircea Ivan; Michael E Boulton; Mervin Yoder; Maria B Grant

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Role of Endoplasmic Reticulum Stress in Angiogenic Progenitor Cells Dysfunction in a Mouse Model of Type 1 Diabetes Open Access

Maulasri Bhatta; Joshua Jianxin Wang; Sarah Xin Zhang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Falls and cataract: investigating risk and predictors in older adults during their wait for surgery Open Access

Lisa J Keay; Anna Palagyi; Kris Rogers; Lynn Meuleners; Peter J McCluskey; Andrew JR White; Jonathon Ng; Nigel Morlet

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Fear of Falling and Postural Reactivity in Patients with Glaucoma Open Access

Fabio B Daga; Alberto Diniz-Filho; Erwin R Boer; Carolina Pelegrini Gracitelli; Ricardo Yuji Abe; Felipe A Medeiros

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Is Vision Loss Linked to Falls among Hospital Inpatients?
Open Access

Susan J Leat; Aleksandra Zecevic; Alexis Keeling; Dylan Brennan; Denise Hileeto; Tammy Labreche; Chris Brymer

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The Impact of Vision Loss on Length of Stay, Readmission and Cost of Inpatient Hospitalization Open Access

Alan R Morse; Paul P Lee; William H Seiple; Nidhi Talwar; Joshua D Stein

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Big data and primary eye care: road accident reporting data and vision in the UK Open Access

Michael Bowen; Carol Hawley; Claire Roberts; Tanya Fosdick

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Longitudinal impact of changes in visual acuity on vision-specific function Open Access

Eva K Fenwick; Peng Guan Ong; Ryan EK Man; Charumathi Sabanayagam; Ching-Yu Cheng; Tien Yin Wong; Preeti Gupta; Ecosse Luc Lamoureux

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Vision-related quality of life in the population-based Gutenberg Health Study (GHS) Open Access

Norbert Pfeiffer; Alexander Karl-Georg Schuster; Rene Hoehn; Thomas Münzel; Philipp S Wild; Dagmar Laubert-Reh; Matthias Michal; Manfred Beutel; Susanne Singer; Karl J Lackner; Stefan Nickels

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

ERG responses to heterochromatic stimuli that reflect L- and M-cone inputs and their additive or opponent interactions Open Access

Jan J Kremers; Deepak Bhatt

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Cocaine- and amphetamine-regulated transcript (CART) regulates retinal dopamine and modulates visual function in mice Open Access

Polina Lyuboslavsky; Curran Sidhu; Jana T Sellers; Li He; P. Michael Iuvone

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Focal ERG analysis on the impact of PCV lesions on retinal function Open Access

Sandeep Kumar; Stephanie VanBeuge; Zachary Berriochoa; Amrita .; Yingbin Fu

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Tauroursodeoxycholic Acid Protects Visual Function in a Mouse Model of Type 1 Diabetes Open Access

Jieming Fu; Moe Aung; Megan Prunty; Adam Hanif; Jeffrey H Boatright; Machelle T Pardue

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

An ex vivo electroretinogram to study spectral mechanisms and cone pathways in the retina Open Access

James A Kuchenbecker; Sara Patterson; Michael B Manookin; Ethan D Buhr; Maureen Neitz; Jay Neitz

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Further evidence of interocular signal transfer in the rodent visual system Open Access

Xiaolan TANG; Radouil T Tzekov; Christopher L Passaglia

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A novel texture-based OCT enface image to detect and monitor glaucoma Open Access

Akram Belghith; Felipe A Medeiros; Christopher Bowd; Robert N Weinreb; Tu Zhuowen; Linda M Zangwill

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Characterization of Errors in Retinopathy of Prematurity (ROP) Diagnosis by International Ophthalmology Residents Open Access

Kai B Kang; Lakshmi Swamy; Samir N Patel; Karyn Jonas; Susan Ostmo; Camila V. Ventura; Maria Ana Martinez-Castellanos; Rachelle Go Ang Sam Anzures; Michael F Chiang; Robison Vernon Paul Chan

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Plus disease: is it more than meets the ICROP? Insights about expert diagnosis from computer-based image analysis Open Access

Michael F Chiang; J. Peter Campbell; Esra Ataer-Cansizoglu; Samir N Patel; James D Reynolds; Kelly Hutcheson; Michael Shapiro; Kimberly A Drenser; Michael Repka; Philip Ferrone; Robison Vernon Paul Chan

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Intraocular Hemorrhage as a Risk Factor for ROP Open Access

R Michael Siatkowski; Gui-Shuang Ying; Ebenezer Daniel; Graham E Quinn

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Foveal Development During the First Year of Life for Premature and Full Term Infants Using Hand-Held Ultra-High Resolution Spectral Domain Optical Coherence Tomography. Open Access

Dr Patel; Samira Anwar; Frank A Proudlock; Irene Gottlob

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

One-Year Outcomes of 49-Channel Suprachoroidal-Transretinal Stimulation (STS) Retinal Prosthesis in Patients with Advanced Retinitis Pigmentosa Open Access

Takashi Fujikado; Motohiro Kamei; Haruhiko Kishima; Takeshi Morimoto; Hiroyuki Kanda; Hirokazu Sakaguchi; Kentaro Nishida; Takao Endo; Koji Osawa; Motoki Ozawa

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Visual function restored by Argus I and Argus II in the same subject Open Access

Lan Yue; Jessy Dana Dorn; Uday Patel; Hassan A Aziz; Lisa C Olmos; James D Weiland; Mark S Humayun

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Preliminary Findings from the Oxford Retinal Implant Alpha AMS Trial Open Access

Thomas L Edwards; Charles L Cottriall; Matthew P Simunovic; James D Ramsden; Eberhart Zrenner; Robert E MacLaren

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Transcorneal electrical stimulation for the treatment of retinitis pigmentosa – Results from the TESOLAUK trial Open Access

Siegfried Karl Wagner; Jasleen Jolly; Maria Pefkianaki; Florian Gekeler; Andrew Webster; Susan Downes; Robert Maclaren

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Successful delivery of rAAV8.CNGA3 in a patient with CNGA3 achromatopsia Open Access

M Dominik Fischer; Barbara Wilhelm; Stylianos Michalakis; Ditta Zobor; Susanne Kohl; Matthias Seeliger; Eberhart Zrenner; Marius Ueffing; Bernd Wissinger; Martin Biel; Karl Ulrich Bartz-Schmidt

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The role of CD24 in age related cataracts Open Access

Ramachandran Balasubramanian; Melinda K Duncan; Yichen Wang

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Knock-down of Tropomyosin 2 created by CRISPR-CAS9 in mouse induces age-related-cataract Open Access

Eri Kubo; Teppei Shibata; Shinsuke Shibata; Hiroshi Sasaki; Etsuko Kiyokawa; Masato Ikawa; Dhirendra P Singh

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Differentiation of pluripotent stem cells to lentoid bodies to model Congenital cataracts Open Access

Zhenwei Qin; Qiuli FU; Lifang Zhang; Ke Yao

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

TGFβ-induced signaling leading to lens epithelial to mesenchymal transition (EMT): Implications for cataract induction Open Access

Magdalena Wojciechowski; Shannon Joel Das; Frank J Lovicu

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Kinostat^TM can Eliminate the Need for Cataract Surgery in Newly Diagnosed Diabetic Dogs Open Access

Peter F Kador; Jane Meza; Milton Wyman; Manley Paulos; Karen Blessing

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

SUMOylation Regulates Vimentin Functions in Lens Open Access

Ling Wang; Zhaoxia Huang; Xiaohui Hu; Yizhi Liu; Quan Dong Nguyen; David W Li

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Characterisation of temporal vision in congenital stationary night blindness Open Access

Rola Ba-Abbad; Andrew Webster; Anthony T Moore; Michel Michaelides; Bart Peter Leroy; Andrew Stockman

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Assessing color vision in congenital achromatopsia Open Access

Emily J Patterson; Christopher S Langlo; Byron L Lam; Christine Nichols Kay; Mark E Pennesi; Richard G Weleber; Gerald A Fishman; William W Hauswirth; Joseph Carroll

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Psychophysical evidence for inhibitory lateral interactions between individual cones in the parafovea Open Access

William Scott Tuten; Wolf M Harmening; Ramkumar Sabesan; Lawrence C. Sincich; Austin Roorda

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Lateral inhibition and spectral opponency in the outer retina of primate Open Access

Brian Patrick Schmidt; Wyeth Bair; Jay Neitz

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Differences in L:M cone ratios obtained with a spatio-chromatic measure and full-field ERG. Open Access

Lene Aarvelta Hagen; Solveig Arnegard; Jon V. B. Gjelle; Stuart J. Gilson; James A Kuchenbecker; Maureen Neitz; Jay Neitz; Rigmor C Baraas

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Red-green balance differences between brown/yellow stimuli over a range of light levels Open Access

Tanner DeLawyer; Rina Nakamura; Steven L Buck

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Role of CFTR in Lacrimal Gland Ductal Fluid Secretion in Mouse Open Access

Edit Toth-Molnar; Mate Katona; Eszter Vizvari; Orsolya Berczeli; Andrea Facsko; Zoltan Rakonczay Jr; Peter Hegyi; Chuanqing Ding

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Formation of functionally competent 3D lacrimal gland cell spheroids - towards regeneration of lacrimal gland tissue Open Access

Isobel Massie; Kristina Spaniol; Gerd Geerling; Marco Metzger; Stefan Schrader

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Protective Role of Commensal Microbiota in the CD25KO Sjögren Syndrome Mouse Model Open Access

Cintia S de Paiva; Mahira Zaheer; Fang Bian; Alton Swennes; Robert A Britton; Stephen C Pflugfelder

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Imbalanced Activation between NLRP3 and NLRP6 by Ocular Innate Immunity in Experimental Dry Eye Mice Open Access

Xin Chen; Wei Chi; Jin Li; Changjun Wang; Fang Bian; Stephen C Pflugfelder; Cintia S De Paiva; De-Quan Li

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Role of IL-1β in Dry Eye Diseases Open Access

Fei Dong; Yujin Zhang; Jianhua Zhang; Chia-Yang Liu; Winston W Y Kao

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Exon usage and splicing variation in mouse age-related meibomian gland dysfunction (ARMGD). Open Access

Emily S. Charlson; Jie Wu; Donald J Brown; James V Jester

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Introduction to Fixational Eye Movements: Consequences for Vision in Maculopathy, Amblyopia, Traumatic Brain Injury, or Neurodegeneration Open Access

Howard S Ying

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Fixational eye movements Open Access

Susana Martinez-Conde

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Disconjugacy of fixational eye movements to detect amblyopia Open Access

Kristina Irsch

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Characteristics of fixation stability in amblyopia and macular disease Open Access

Susana T L Chung

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Fixation instability and amblyopia Open Access

Eileen E Birch

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Fixation Stability: Potential Roles of Microperimetry in the Management of Maculopathy Open Access

Quan Dong Nguyen

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Detecting fixation accuracy/stability using retinal birefringence scanning Open Access

David G Hunter

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Mincle activation and Syk/Card9 signaling axis are central to development of autoimmune disease of the eye Open Access

Holly Lallman Rosenzweig; Brieanna Brown; Paige Snow; Emily Vance; Phyllis Silver; Rachel R Caspi; Ellen J Lee

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

IL-17A is dispensable for spontaneous autoimmune uveitis and negatively regulates the Th17 cytokine program
Open Access

Wai Po Chong; Reiko Horai; Phyllis Silver; Yingyos Jittayasothorn; Chi-Chao Chan; Rachel R Caspi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The lectin but not classical pathway of activation is important for complement to regulate the development of experimental autoimmune uveitis Open Access

Lingjun Zhang; Brent A Bell; Yan Li; Xiaomin Zhang; John Fung; Rachel R Caspi; Feng Lin

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Microglia and monocyte-derived macrophage responses to light damage differ across mouse strains Open Access

Emily Okoren; Rose Mathew; Daniel R Saban

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Permeability of Bruch’s membrane to complement proteins: Implications for translational medicine in AMD Open Access

Simon John Clark; Selina McHarg; Nicole Brace; Paul N Bishop

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The aged Cxcr5 knockout mice develop the features of age-related macular degeneration Open Access

Hu Huang; WEN LI; Gerard A Lutty

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Introduction Open Access

William J Brunken

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Trabecular Meshwork EMC in Glaucoma Open Access

Ted S Acott

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Genes encoding the extracellular matrix proteins SPACR (IMPG1) and SPACRCAN (IMPG2) cause macular vitelliform dystrophies Open Access

Christian P Hamel

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Extracellular matrix in retinal vascular development and pathological angiogenesis Open Access

Paul N Bishop

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Using the Extracellular Matrix to Engineer Stem Cell Therapies for Ocular Disease Open Access

Dennis O Clegg

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Summary and Future Directions Open Access

Douglas B Gould

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Degradation of Basement membrane Protein is Significantly Reduced in Glaucomatous Trabecular meshwork Open Access

Sanjoy K Bhattacharya; Teresia Carreon; Genea T Edwards

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The role of pigment epithelium-derived factor in the progression of primary open angle glaucoma Open Access

Richard J Blanch; Lisa J Hill; Jenna O'Neill; Philip Ian Murray; Imran Masood; Ann Logan; Zubair Ahmed

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Structures of myocilin olfactomedin domain variants provide new clues into its misfolding and elusive function Open Access

Raquel L Lieberman; Shannon Hill; Michelle Kwon

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Extracellular matrix remodeling and immune activation in glaucomatous PTP-Meg2 deficient mice Open Access

Jacqueline Reinhard; Julia Woestmann; Susanne Wiemann; Stephanie C Joachim; Andreas Faissner

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Myocilin is a modulator of TIMP3 activity Open Access

Stanislav I Tomarev; Myung Kuk Joe

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Association of miR-182 with High Tension Glaucoma Open Access

Yutao Liu; Jessica Cooke Bailey; Inas Helwa; W Daniel Stamer; Rachel W Kuchtey; R Rand Allingham; Michael A Hauser; Louis R Pasquale; Jonathan L Haines; Janey L Wiggs

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Pupillary light reflexes in non-proliferative diabetic retinopathy. Open Access

J Jason McAnany; Jason C Park; Norman P Blair; Felix Yan-Fay Chau; Jennifer I Lim; Yannek Isaac Leiderman; Mahnaz Shahidi

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Dark rearing slows deterioration of retinal ganglion cell light-evoked responses in rd10 mice and extends a period of immature retinal ganglion cell physiology Open Access

Steven F Stasheff; Malini Shankar

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Vascular endothelial growth factor (VEGF) and bradykinin induce increased electroretinogram amplitude and decreased visual acuity. Open Access

Allen C Clermont; Nivetha Murugesan; Cheng-mao Lin; Sarah R Sheskey; David A Antonetti; Edward P Feener

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Regulating arachidonic acid metabolites ameliorates neurovascular defects and subsequent visual deficits in STZ rats Open Access

Adam Hanif; Moe Aung; Megan Prunty; Hanna Park; P. Michael Iuvone; Machelle T Pardue

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Longitudinal evaluation of structural and functional changes in the optic nerve head and inner retina in experimental glaucoma Open Access

Lakshmi Priya Rajagopalan; Nimesh Bhikhu Patel; Kevin M Ivers; Nripun Sredar; Hope M Queener; Jason Porter; Ronald S Harwerth; Laura J Frishman

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Optogenetic engineering of retinal ganglion cells with AAV2.7m8-ChrimsonR-tdTomato (GS030) in combination with an event-based camera photostimulation device Open Access

Jose Sahel; Deniz Dalkara; Jens Duebel; Ryad Benosman; Guillaume Chenegros; Anne Douar; Joël Chavas; Céline Bouquet; Didier Pruneau; Botond Roska; Serge A Picaud

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The photopic negative response: an objective measure of retinal ganglion cell in patients with Leber's Hereditary Optic Neuropathy Open Access

Rustum Karanjia; Adriana Berezovsky; Paula Y Sacai; Milton N de Moraes-Filho; Nivea Nunes Cavascan; Solange Rios Salomao; Sung Eun Song Watanabe; Rubens Belfort; Vallerio Carelli; Stuart G Coupland; Alfredo A Sadun

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The First Steps in Vision: Cell types, Circuits and Repair Open Access

Botond Roska

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Medical Science and Future Realities in Corneal Regenerative Medicine Open Access

Shigeru Kinoshita

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Dynamics of autophagy and mitophagy in neuronal homeostasis and neurodegeneration Open Access

Erika Holzbaur

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

What age-related macular degeneration taught us about aging of the retinal pigment epithelium Open Access

Christine A Curcio

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Immune mechanisms in the eye and aging Open Access

Rajendra S Apte

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Progress and challenges in genetic and epigenetic epidemiology of age-related eye diseases Open Access

Ching-Yu Cheng

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Age and oxidative stress in the retina Open Access

James T Handa

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

A full lifespan model of lens growth Open Access

Steven Bassnett

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

The role of transcellular mitophagy in glaucoma Open Access

Nicholas Marsh-Armstrong

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Mitochondrial dysfunction in the pathogenesis of age-related macular degene Open Access

Deborah A Ferrington

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Autophagic dysregulation in glaucomatous trabecular meshwork cells Open Access

Paloma B Liton

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Altered autophagy flux in granular corneal dystrophy type 2 Open Access

Eung Kweon Kim

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Autophagy in retinal degenerations Open Access

Claire H Mitchell

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:

Mitophagy in Fuchs Endothelial Corneal Dystrophy Open Access

Ula V Jurkunas

Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi: