October 1974
Volume 13, Issue 10
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Articles  |   October 1974
Fine Structure of Experimental Cyanide Optic Neuropathy
Author Affiliations
  • SIMMONS LESSELL
    Departments of Ophthalmology and Neurology, Boston University School of Medicine, Boston, Mass., Laboratory of Vision Research, National Eye Institute, United States Department of Health, Education Welfare, Bethesda, Md.
  • TOICHIRO KUWABARA
    Departments of Ophthalmology and Neurology, Boston University School of Medicine, Boston, Mass., Laboratory of Vision Research, National Eye Institute, United States Department of Health, Education Welfare, Bethesda, Md.
Investigative Ophthalmology & Visual Science October 1974, Vol.13, 748-756. doi:https://doi.org/
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      SIMMONS LESSELL, TOICHIRO KUWABARA; Fine Structure of Experimental Cyanide Optic Neuropathy. Invest. Ophthalmol. Vis. Sci. 1974;13(10):748-756. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Within 48 hours after an intraperitoneal injection of sodium cyanide, abnormalities are evident in the retrobulbar portion of rat optic nerves. Electron microscopy initially shows swelling of astrocytes but progressively increasing damage, primarily to axones, is evident later. Six weeks after intoxication the retrobulbar segment of the nerves are devastated but the retinas and prechiasmal portion of the nerves have minor, and presumably secondary, lesions.

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