December 1962
Volume 1, Issue 6
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Articles  |   December 1962
The Mode of Action of Pilocarpine on Outflow Resistance in the Eye Primate (Cercopithecus Ethiops)
Author Affiliations
  • ERNST H. BÁRÁNY
    Department of Physiology, School of Medicine, Makerere College Kampala, Uganda Department of Pharmacology, University of Uppsala Sweden.(permanent address of author).
Investigative Ophthalmology & Visual Science December 1962, Vol.1, 712-727. doi:https://doi.org/
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      ERNST H. BÁRÁNY; The Mode of Action of Pilocarpine on Outflow Resistance in the Eye Primate (Cercopithecus Ethiops). Invest. Ophthalmol. Vis. Sci. 1962;1(6):712-727. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Facility of outflow in the eye of the vervet monkey Cercopithecus ethiops ivas studied by constant-rate and by constant-pressure infusion. Facility increased greatly after the injection of 2 to 3 mg of pilocarpine into the anterior chamber or after the application of 0.2 to 0.3 mg. to the cornea. The effect on facility consisted of 2 components. One component was reversed in 3 to 5 minutes by 1 mg. per kilogram intravenous atropine, the time it took for the atropine to relax pilocarpine-induced accommodation. The other component was reversed only slowly by intravenous or even intracameral atropine. The slowly reversed component teas thought to represent a pilocarpine action directly on the endothelial cells of the outflow system, possibly a histamine-like action on the endothelial wall of Schlemm's canal.

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