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Tos T. J. M. Berendschot, R. Alexandra Goldbohm, Wilhelmina A. A. Klöpping, Jan van de Kraats, Jeannette van Norel, Dirk van Norren; Influence of Lutein Supplementation on Macular Pigment, Assessed with Two Objective Techniques. Invest. Ophthalmol. Vis. Sci. 2000;41(11):3322-3326.
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purpose. Macular pigment (MP) may protect against age-related macular
degeneration. This study was conducted to determine the extent of
changes in the macular pigment density as a consequence of oral
supplementation with lutein. A second purpose was to compare two
objective measurement techniques.
methods. In the first technique, reflectance maps were made with a scanning
laser ophthalmoscope. Digital subtraction of log reflectance maps and
comparison between the foveal area and a 14° temporal site provided
MP density estimates. In the second technique, spectral fundus
reflectance of the fovea was measured with a fundus reflectometer and
analyzed with a detailed optical model, to arrive at MP density values.
Eight subjects participated in this study. They took 10 mg lutein per
day for 12 weeks. Plasma lutein concentration was measured at 4-week
results. After 4 weeks, mean blood level of lutein had increased from 0.18 to
0.90 μM. It stayed at this level throughout the intake period and
declined to 0.28 μM 4 weeks after termination. Measurement of the
density of MP showed a within-subject variation of 10% with MP maps
and 17% with spectral reflectance analysis. MP density showed a mean
linear 4-week increase of 5.3% (P < 0.001) and 4.1%
(P = 0.022), respectively.
conclusions. Supplementation with lutein significantly increased the density of the
MP. Analyzing reflectance maps with a scanning laser ophthalmoscope
provided very reliable estimates of MP.
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