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Hermann Dieter Schworm, Armin Ernst Heufelder, Andrea Kunze, Esther Welge, Klaus–Peter Boergen; Clinical Significance of Saccade Analysis in Early Active Graves’ Ophthalmopathy. Invest. Ophthalmol. Vis. Sci. 2000;41(7):1710-1718.
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purpose. To assess whether saccadic eye movements show distinct changes in
patients with early active Graves’ ophthalmopathy (GO), which could
serve as a diagnostic tool for early detection and treatment.
methods. Each of two prospective studies included 10 patients with early acute
GO and 10 age- and sex-matched control subjects. In the explorative
study (ES) 15 dynamic parameters of saccades were analyzed. In the
comparative study (CS) only those parameters were evaluated, which in
ES had shown significant differences between patients and controls.
Horizontal and vertical saccades of 10°, 20°, and 40° including a
fatigue test were recorded binocularly using the induction scleral
results. The differences of saccadic dynamics between patients and controls were
small, whereas intra- and interindividual standard deviations were
large. In ES, 7.1% of the parameters showed significant differences at
a level of P ≤ 0.05. In CS, 2.1% of all parameters revealed
repetitive significant differences. Despite statistical significance,
individual data did not allow differentiation between patients and
healthy individuals due to high standard deviations.
conclusions. In early active GO no clinically relevant saccadic changes were
detected. These findings may be based on adaptation of the central
saccadic generator. Inclusion of patients with fibrotic muscle changes
due to long-standing disease could explain the contrasting results of
previous studies. Consequently, analysis of saccades does not serve as
a diagnostic tool during early active GO.
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