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Anne Kurtenbach, Hana Langrova, Eberhart Zrenner; Multifocal Oscillatory Potentials in Type 1 Diabetes without Retinopathy. Invest. Ophthalmol. Vis. Sci. 2000;41(10):3234-3241.
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purpose. To study multifocal recordings of oscillatory potentials (m-OPs) in
diabetic (Type 1) eyes that have no visible fundus alterations, to
ascertain whether topographical changes in sensitivity are evident when
compared with recordings from control subjects.
methods. The Visual Evoked Response Imaging System (VERIS; EDI, San Diego, CA)
system was used to elicit m-OPs from 61 independent areas, subtending
the central 30° of the retina, from 24 eyes of 12 patients with
diabetes without retinopathy and from 26 eyes of 14 control subjects.
For each group of subjects, the mean first- and second-order (first
slice) kernel components of the responses for one eye, randomly chosen
from each subject, were analyzed and compared for a retinal ring
analysis and for an analysis of retinal quadrants.
results. Both first- and second-order kernel responses of the diabetic group
show significant delays in the implicit times of some of the m-OPs,
compared with those of the control group. No significant changes in
amplitude were found. For the first-order component, significant
differences are found for both potentials between 5° and 22°
eccentricity, for the nasal retina, and for one of the potentials for
the remaining retinal areas. In the second-order kernel responses, the
differences are significant for two of the three potentials in the
midperiphery between 5° and 13° eccentricity, with the central
potential being significantly delayed in all rings and quadrants.
conclusions. Patients with diabetes without retinopathy show prolonged latencies in
m-OP recordings. This indicates an alteration in inner retinal
sensitivity that can be explained by an impaired rod–cone
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