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Masayoshi Tachibana, Yasuhito Kobayashi, Takashi Kasukabe, Kaname Kawajiri, Yoshibumi Matsushima; Expression of Androgen Receptor in Mouse Eye Tissues. Invest. Ophthalmol. Vis. Sci. 2000;41(1):64-66.
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© ARVO (1962-2015); The Authors (2016-present)
purpose. To test the possibility that androgen directly affects the corneal
cells, the possible occurrence of androgen receptor (AR) in the cornea
and other eye tissues of mice was examined.
methods. To examine the occurrence of AR protein in the mouse eye tissues, an
immunocytochemical method was used. To examine the occurrence of AR
mRNA in the cornea and lens, reverse transcription–polymerase chain
reaction (RT–PCR) was used.
results. Immunocytochemical examination revealed that antigenicity for AR
antibody exists in cell nuclei of cornea, lens, iris, and ciliary body
of both male and female mice. RT–PCR revealed that mRNA of AR occurs
in the cornea and lens of both male and female mice.
conclusions. It is concluded that AR occurs in cells of cornea, lens, iris, and
ciliary body of the mouse eye. Androgen may affect cells in these
tissues directly through interaction with AR.
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