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Nilza Minguini, Keila M. Monteiro de Carvalho, Patrícia M. S. Akaishi, Iara M. S. De Luca; Histologic Effect of Mitomycin C on Strabismus Surgery in the Rabbit. Invest. Ophthalmol. Vis. Sci. 2000;41(11):3399-3401.
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purpose. To evaluate the efficiency of mitomycin C (MMC) in limiting the
postoperative inflammatory response and scarring after strabismus
methods. A prospective, two-stage, masked, controlled trial was conducted. In
the first stage, the inflammatory response at the extraocular muscle
reattachment site was increased after inferior rectus recession in
eight rabbits. In the second stage, MMC (0.4 mg/ml) was applied during
surgery to the eyes of 22 rabbits with inferior rectus recession. As a
control, contralateral eyes were treated with saline solution. Seven
weeks later, exenteration was performed, and the sites of muscle
reattachment were processed for histologic examinations. The sums of
the areas of the granulomas in the extraocular muscle reattachment
sites of control and treated eyes were compared.
results. There was no significant inhibitory effect of MMC on the inflammatory
response of treated eyes compared with that of control eyes.
conclusions. The intraoperative use of MMC (0.4 mg/ml) was not effective in
controlling the postoperative inflammatory response in rabbit eyes
after extraocular muscle surgery. These data do not support the
hypothesis that MMC reduces postoperative adhesions after strabismus
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