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Shigeru Hasegawa, Mineo Takagi, Tomoaki Usui, Ritsuko Takada, Haruki Abe; Waveform Changes of the First-Order Multifocal Electroretinogram in Patients with Glaucoma. Invest. Ophthalmol. Vis. Sci. 2000;41(6):1597-1603.
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purpose. To investigate the relationship between the components of the
first-order multifocal electroretinogram (M-ERG) and glaucomatous
visual field loss.
methods. Twenty-six eyes of 14 patients with primary open-angle glaucoma (POAG)
were evaluated with the M-ERG techniques. Twenty-six eyes of 26 normal
subjects also were tested as control subjects. To record the M-ERG, a
stimulus matrix of 103 scaled hexagonal elements was displayed on a
monitor driven at a 75-Hz frame rate according to a binary m-sequence.
The M-ERG responses were averaged in each quadrant of the stimulus
field and the peak-to-trough amplitudes and peak implicit times of the
first trough (N1), the first peak (P1), and the second trough (N2) of
the M-ERG were compared with the mean sensitivity values (dB) of the
corresponding quadrant of the Humphrey static perimetric field.
results. The changes in the peak latencies of P1 and N2 in the POAG group were
small but significant compared with those in the normal group
(P < 0.01). However, no significant differences in
the amplitudes of (P1–N1) and (P1–N2) between the two groups were
found. Significant negative correlations between the peak implicit
times of N1, P1, and N2 and the mean sensitivity values (dB) of static
perimetry were observed. The correlation coefficients were −0.20
(P < 0.05) for the N1, −0.41
(P < 0.001) for the P1, and −0.59
(P < 0.001) for the N2. No significant
correlations were observed between the amplitudes (P1–N1 and P1–N2)
and the mean sensitivity values.
conclusions. The present study findings suggest that the peak implicit times, but
not the amplitudes, of the M-ERG increase as the glaucomatous visual
field deteriorates. The amplitudes of the M-ERG did not decrease as the
glaucomatous optic nerve dysfunction
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