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Andreas Remky, Oliver Arend, Stefan Hendricks; Short-Wavelength Automated Perimetry and Capillary Density in Early Diabetic Maculopathy. Invest. Ophthalmol. Vis. Sci. 2000;41(1):274-281.
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purpose. To correlate short-wavelength cone-mediated sensitivity (SWS) assessed
by blue-on-yellow perimetry with alterations of the perifoveal vascular
bed in early diabetic maculopathy.
methods. Thirty-one patients (21 M, 10 F; mean age, 35 ± 12 years; no lens
opacities) with no clinically significant macular edema were included
in this study. All patients underwent short-wavelength automated
perimetry (SWAP) and conventional white-on-white perimetry (Humphrey,
10-2). In digitized video fluorescein angiograms (Scanning Laser
Ophthalmoscope), the size of the foveal avascular zone (FAZ) and the
mean perifoveal intercapillary area (PIA) as a measure of capillary
density were quantified interactively.
results. Mean thresholds of SWAP were significantly correlated with increasing
size of FAZ (r = −0.51, P =
0.003) and PIA (r = −0.47, P =
0.01), whereas visual acuity expressed by log MAR (FAZ: r = 0.15, P = 0.41; PIA: r = 0.06, P = 0.76) and mean
thresholds assessed with white-on-white perimetry (FAZ: r = −0.25, P = 0.20; PIA: r = −0.31, P = 0.14) were
unrelated to diabetic changes of the perifoveal capillary network.
conclusions. The alterations of the perifoveal network are related to selective
disturbances of visual function as measured by
blue-on-yellow-perimetry. SWAP may act as an early detector of visual
function loss in early diabetic maculopathy and serve as a helpful
technique to predict early ischemic damage of the macula and to monitor
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