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Ronald M. Hansen, Anne B. Fulton; Background Adaptation in Children with a History of Mild Retinopathy of Prematurity. Invest. Ophthalmol. Vis. Sci. 2000;41(1):320-324.
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purpose. In children with a history of mild retinopathy of prematurity (ROP),
test the hypothesis that elevation of the parafoveal over peripheral
dark-adapted threshold is due to photoreceptor rather than postreceptor
methods. A forced choice procedure was used to measure thresholds for detection
of 2o diameter, 50 msec, blue stimuli presented
10o (parafoveal) or 30o (peripheral) eccentric
in the dark and in the presence of steady red backgrounds (−4 to +2
log scot td). Four ROP and four control subjects were tested at both
eccentricities. A model of the increment threshold function was fit to
the data to calculate the eigengrau and dark-adapted
results. Both ROP subjects with elevated parafoveal thresholds also have
elevated parafoveal eigengraus. On the other hand,
parafoveal and peripheral eigengraus are equal in ROP
subjects without parafoveal threshold elevation. Nevertheless, the
dark-adapted thresholds of all ROP subjects are higher than those of
any control subject at both sites.
conclusions. The parafoveal threshold elevation is due to rod dysfunction. There is
also evidence of peripheral rod photoreceptor involvement in the
subjects with ROP.
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