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Boel Bengtsson, Anders Heijl; False-Negative Responses in Glaucoma Perimetry: Indicators of Patient Performance or Test Reliability?. Invest. Ophthalmol. Vis. Sci. 2000;41(8):2201-2204.
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purpose. To study whether false-negative answers in computerized glaucoma
perimetry indicate the patient’s ability to perform perimetry or test
methods. A retrospective evaluation was performed of visual field test results
obtained with a perimetry program (Humphrey 30-2 Sita Standard;
Humphrey Instruments, San Leandro, CA) in 70 consecutive patients with
unilateral glaucomatous field loss. Frequencies of false-negative
answers were compared between the two eyes of each patient and related
to amount of visual field damage in the glaucomatous eyes using linear
results. Frequencies of false-negative answers were higher in eyes with field
loss. The intrapatient intereye difference was 6.6% on average
(P < 0.0001). In seven subjects with
false-negative frequency of 5% or more in both eyes, the mean
difference was 12.7% between eyes. The differences in false-negative
answers depended significantly on the amount of field loss in the
glaucomatous eyes (P = 0.0003). Larger differences
were seen in patients with advanced field loss in the affected eye.
conclusions. The increased frequencies of false-negative answers in eyes with field
loss were strongly associated with field status. The higher
false-negative frequencies in eyes with glaucomatous field loss
compared with unaffected eyes may be explained by the increased
variability in threshold values typically found in such eyes.
False-negative answers in patients with glaucoma therefore represent
eye rather than patient status.
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