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Dennis Shun Chiu Lam, Wing Shan Lee, Yuk Fai Leung, Pancy Oi Sin Tam, Dorothy S. P. Fan, Bao Jian Fan, Chi Pui Pang; TGFβ-Induced Factor: A Candidate Gene for High Myopia. Invest. Ophthalmol. Vis. Sci. 2003;44(3):1012-1015. doi: 10.1167/iovs.02-0058.
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purpose. To investigate the coding exons of transforming growth factor (TGF)-β–induced factor (TGIF) for mutations in Chinese patients with high myopia.
methods. Seventy-one individuals with high myopia of −6.00 D or less and 105 control subjects were screened by DNA sequencing for sequence alterations. Univariate analysis and logistic regression were performed to identify single-nucleotide polymorphisms (SNPs) and their interactions in TGIF that may be associated with myopia.
results. Six SNPs showed a significant difference (P < 0.05) between patient and control subject in univariate analysis. Four of them cause codon changes: G223R, G231S, P241T, and A262G. Among all the SNPs that entered multivariate analysis, only 657(T→G) showed statistical significance in the logistic regression model (odds ratio 0.133; 95% confidence interval 0.037–0.488; P = 0.002).
conclusions. TGIF is a probable candidate gene for high myopia. Further studies are needed to identify the underlying mechanism.
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