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Louis Tong, Seang-Mei Saw, Jyh-Kuen Siak, Gus Gazzard, Donald Tan; Corneal Thickness Determination and Correlates in Singaporean Schoolchildren. Invest. Ophthalmol. Vis. Sci. 2004;45(11):4004-4009. doi: 10.1167/iovs.04-0121.
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purpose. To determine the central cornea thickness (CCT) in Singaporean children and to examine the possible relationship between intraocular pressure (IOP) and other biometric factors and CCT.
methods. This was a cross-sectional study. The subjects (N = 652) were obtained from the Singapore Cohort Study of the Risk Factors for Myopia (SCORM). The subjects’ ages ranged from 9 to 11 years. There were 485 Chinese, 92 Malayan, and 75 Asian Indian children. Measurement procedures included air-puff tonometry, noncontact slit lamp optical pachymetry, cycloplegic autorefraction, and autokeratometry.
results. The mean CCT was 543.6 ± 32.0 μm. Chinese children had thicker corneas than Malayan or Indian children (P = 0.002). The boys had thicker corneas than girls (P = 0.011), but the mean difference was only 6.4 μm. There was high correlation of CCT (r = 0.98) and IOP (r = 0.88) between right and left eyes. IOP was correlated with CCT (r = 0.45, P < 0.001). In a multiple linear regression model, each millimeter of mercury of IOP was associated with a CCT difference of 5.90 μm (95% confidence interval [CI], 4.98–6.82). The radius of corneal curvature correlated with CCT (r = 0.19, P < 0.001). The following parameters were not significantly (P > 0.05) associated with CCT: age, family income, father’s education, axial length, and spherical equivalent.
conclusions. The mean CCT in Singaporean children aged 9 to 11 years was 543.6 μm and showed ethnic and gender variation. CCT affected measured IOP and correlated weakly with corneal curvature. Compared with data in adults, a change in CCT was associated with a greater difference in measured IOP.
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