October 1965
Volume 4, Issue 5
Free
Articles  |   October 1965
Topical Corticosteroids and Galactose Cataracts
Author Affiliations
  • EDWARD COTLIER
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.
  • BERNARD BECKER
    Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Mo.
Investigative Ophthalmology & Visual Science October 1965, Vol.4, 806-814. doi:
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      EDWARD COTLIER, BERNARD BECKER; Topical Corticosteroids and Galactose Cataracts. Invest. Ophthalmol. Vis. Sci. 1965;4(5):806-814.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Lens changes were followed in galactose-fed rats treated topically with betamethasone to one eye only. Cataractous changes in eyes receiving topical corticosteroids appeared earlier and developed more rapidly than in contralateral untreated eyes or in eyes of galactose-fed rats receiving no steroids. A few of the possible mechanisms of the steroid effects (86Rb uptake, dulcitol accumulation, and aldolase activity) were explored. Although these were altered in galactose-fed animals, no significant differences were noted between the lenses of corticosteroidtreated and contralateral eyes.

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