December 1965
Volume 4, Issue 6
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Articles  |   December 1965
Estimation of Retinal Blood Flow in Animals
Author Affiliations
  • Ephraim Friedman
    Howe Laboratory of Ophthalmology, Harvard University Medical School, and Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass.
  • Taylor R. Smith
    Howe Laboratory of Ophthalmology, Harvard University Medical School, and Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass.
  • Susan Mimura Oak, technical assistance
    Howe Laboratory of Ophthalmology, Harvard University Medical School, and Eye Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Mass.
Investigative Ophthalmology & Visual Science December 1965, Vol.4, 1122-1128. doi:
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      Ephraim Friedman, Taylor R. Smith, Susan Mimura Oak; Estimation of Retinal Blood Flow in Animals. Invest. Ophthalmol. Vis. Sci. 1965;4(6):1122-1128.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The applicability of the krypton-85 (85Kr) clearance method to the study of retinal blood flow in cats, rabbits, and monkeys is discussed. 85Kr disappearance curves are found to be the same whether the isotope is injected via the common carotid artery or via the lateral long posterior ciliary artery. 85Kr disappearance curves are found to be similar whether the radioactivity is monitored with a Geiger-Muller (beta) probe, a solid state (beta) probe, or a scintillation (gamma) probe. Using the initial slope method of analyzing the 85Kr disappearance curves, the average rate of blood flow to the retina (from choroidal and retinal vessels) is estimated at 800 ml. per 100 Gm. of retinal tissue per minute

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