October 1965
Volume 4, Issue 5
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Articles  |   October 1965
Studies on the Cornea
Author Affiliations
  • GORDON I. KAYE
    F. Higginson Cabot Laboratory of Electron Microscopy, Division of Surgical Pathology of the Departments of Surgery and Pathology, College of Physicians and Surgeons, Columbia University, New York, N. Y.
  • ANTHONY DONN
    F. Higginson Cabot Laboratory of Electron Microscopy, Division of Surgical Pathology of the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, N. Y.
Investigative Ophthalmology & Visual Science October 1965, Vol.4, 844-852. doi:
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      GORDON I. KAYE, ANTHONY DONN; Studies on the Cornea . Invest. Ophthalmol. Vis. Sci. 1965;4(5):844-852.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

This study is concerned with the morphological manifestations of ouabain treatment as reflected in corneal thickness and pinocytosis. Administration of ouabain in vivo or in vitro leads to corneal swelling and a marked reduction in the number of pinocytotic vesicles in the endothelium. A comparison of ouabain-treated, cold-inhibited, and neonatal corneas, as well as consideration of electron histochemical studies on ATPase distribution in the cornea, suggests that a common mechanism may underlie the morphological changes and that the pinocytotic transport system in the corneal endothelium may be dependent on an electrolyte transport system for proper function.

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