August 1965
Volume 4, Issue 4
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Articles  |   August 1965
Amino Acid Transport in the Lens
Author Affiliations
  • V. EVERETT KINSEY
    Kresge Eye Institute, Detroit, Mich.
Investigative Ophthalmology & Visual Science August 1965, Vol.4, 691-699. doi:
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      V. EVERETT KINSEY; Amino Acid Transport in the Lens. Invest. Ophthalmol. Vis. Sci. 1965;4(4):691-699.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Most amino acids usually found in other tissues are present in the lens. In the rabbit all of these compounds are in concentrations higher than those in the aqueous humors and much higher than concentrations in vitreous humor. Accumulation takes place through active transport by processes which require glucose, the anaerobic utilization of which can provide all the energy needed to maintain normal concentration gradients. The mechanisms responsible for transport of amino acids are probably confined to the epithelium, are highly temperature dependent, can be inhibited by various metabolic poisons and selectively, in varying degrees, by each other. At least three systems, one each for neutral, acidic, and basic amino acids, appear to be involved in their active transport. The steady state concentration of amino acids in the lens is determined by the balance between the rate of entrance through active transport and exit by diffusion.

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