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Lene D. Sjö, Elisabeth Ralfkiaer, Jan U. Prause, Jorgen H. Petersen, Jakob Madsen, Niels T. Pedersen, Steffen Heegaard; Increasing Incidence of Ophthalmic Lymphoma in Denmark from 1980 to 2005. Invest. Ophthalmol. Vis. Sci. 2008;49(8):3283-3288. doi: 10.1167/iovs.08-1768.
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purpose. To evaluate patient characteristics and incidence of ophthalmic lymphoma in Denmark during the period 1980 to 2005.
methods. All patients in Denmark with a diagnosis of ophthalmic lymphoma during the period 1980 to 2005 were retrieved from three different population-based registries. Specimens from all patients were collected and reclassified according to the World Health Organization (WHO) classification system. Incidence rates were calculated by using Poisson regression models.
results. A total of 228 patients with a histologically verified diagnosis of ophthalmic lymphoma were included. There was an equal distribution of males and females. The most frequent lymphoma subtype was extranodal marginal zone B-cell lymphoma (MALT [mucosa-associated lymphoid tissue] lymphoma, 55.5%) and most cases were located in the orbit (56.8%). High-grade lymphoma subtypes were found more frequently in males than in females. Incidence rates were highly dependent on the patient’s age. For all ages, a statistically significant annual average increase of 3.4% during the 26-year period was found. This increase was primarily due to a rise in the incidence of MALT lymphoma.
conclusions. In the Danish population ophthalmic lymphoma consists primarily of orbital MALT lymphoma. Although it is a rare disease in mostly elderly patients, the incidence of ophthalmic lymphoma is increasing at a rapid pace.
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