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Veronique Vitart, Goran Benčić, Caroline Hayward, Jelena Škunca Herman, Jennifer Huffman, Susan Campbell, Kajo Bućan, Lina Zgaga, Ivana Kolčić, Ozren Polašek, Harry Campbell, Alan Wright, Zoran Vatavuk, Igor Rudan; Heritabilities of Ocular Biometrical Traits in Two Croatian Isolates with Extended Pedigrees. Invest. Ophthalmol. Vis. Sci. 2010;51(2):737-743. doi: 10.1167/iovs.09-3720.
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© 2015 Association for Research in Vision and Ophthalmology.
Purpose. To assess the effects of body stature and years of education, in addition to age and sex, on six oculometric traits and to estimate the heritabilities of these quantitative traits in two Croatian cross-population studies.
Methods. Adult subjects living on the two Croatian islands of Vis and Korčula were recruited for a large epidemiologic and genetic study that included eye biometry, keratometry, and autorefraction. Effects and heritabilities were estimated by using general linear mixed models for axial length (AL), anterior chamber depth (ACD), corneal curvature (CC), corneal thickness (CT), lens thickness (LT), and spherical equivalent refraction (SER). Both cohorts were genotyped with dense SNP arrays, allowing the use of kinship coefficients derived from genotypic data (realized kinship) rather than from pedigree information (expected kinship).
Results. Across cohorts, body mass index (BMI) did not consistently influence any of the ocular traits adjusted for age and/or sex, whereas height and years in education (YrEd) did, explaining up to an additional 5% of the variance (in CC). CT was the trait least influenced by covariates. Estimated heritabilities in Vis and Korčula, respectively, were 84% and 52% for CC, 75% and 71% for CT, 37% and 32% for LT, 59% and 45% for ACD, 37% and 74% for AL, and 0% and 17% for SER.
Conclusions. While heritabilities of CT and CC seemed uniformly high across studies of Caucasian datasets, estimates for SER varied widely and were at the lower end of the spectrum of published observations in our study.
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