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Naveed Nilforushan, Nariman Nassiri, Sasan Moghimi, Simon K. Law, JoAnn Giaconi, Anne L. Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi; Structure–Function Relationships between Spectral-Domain OCT and Standard Achromatic Perimetry. Invest. Ophthalmol. Vis. Sci. 2012;53(6):2740-2748. doi: 10.1167/iovs.11-8320.
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© ARVO (1962-2015); The Authors (2016-present)
To explore structure–function relationships in early glaucoma with spectral-domain optical coherence tomography (SD-OCT) and standard achromatic perimetry.
One hundred thirty-six eyes of 97 patients with suspected or early glaucoma were enrolled from the clinical database at UCLA's Glaucoma Division. All patients had good-quality peripapillary retinal nerve fiber layer (RNFL)/optic disc measurements and a reliable 24-2 SITA-Standard Humphrey visual field (VF) within a 6-month period. Correlations of global and sectoral RNFL thickness and rim area (RA) measurements, with corresponding global and regional VF sensitivities (both in logarithmic [dB] and 1/Lambert scales [1/L]), were investigated with components of variance models.
The average RNFL thickness, RA, and mean deviation (MD) were 85.6 ± 5.7 μ, 1.0 ± 0.3 mm2, and −1.3 ± 1.9 dB, respectively. Global RA demonstrated a stronger correlation with MD compared to average RNFL thickness (P = 0.002). The highest correlations were observed between superonasal VF cluster (in dB scale) and inferotemporal RA (R 2 = 0.26, 95% CI: 0.15–0.40) or inferotemporal RNFL thickness (R 2 = 0.24, 95% CI: 0.13–0.37). In glaucoma suspects, the highest correlations were seen between superonasal VF cluster and inferotemporal RA (R 2 = 0.16) in dB scale or RNFL thickness (R 2 = 0.10) in 1/L scale. Correlations were slightly greater with dB scale than 1/L scale and tended to be linear with both scales.
Structure–function relationships can be detected in early glaucoma with SD-OCT. Correlations of RA with VF thresholds tended to be higher compared to those of RNFL. Structure–function relationships were well described with a linear model.
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