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John C Hwang, Ranjith Konduru, Xinbo Zhang, Ou Tan, Brian A Francis, Rohit Varma, Mitra Sehi, David S Greenfield, SriniVas R Sadda, David Huang; Relationship among Visual Field, Blood Flow, and Neural Structure Measurements in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2012;53(6):3020-3026. doi: 10.1167/iovs.11-8552.
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© 2015 Association for Research in Vision and Ophthalmology.
Purpose. To determine the relationship among visual field, neural structural, and blood flow measurements in glaucoma.
Methods. Case-control study. Forty-seven eyes of 42 patients with perimetric glaucoma were age-matched with 27 normal eyes of 27 patients. All patients underwent Doppler Fourier-domain optical coherence tomography to measure retinal blood flow and standard glaucoma evaluation with visual field testing and quantitative structural imaging. Linear regression analysis was performed to analyze the relationship among visual field, blood flow, and structure, after all variables were converted to logarithmic decibel scale.
Results. Retinal blood flow was reduced in glaucoma eyes compared to normal eyes (P < 0.001). Visual field loss was correlated with both reduced retinal blood flow and structural loss of rim area and retinal nerve fiber layer (RNFL). There was no correlation or paradoxical correlation between blood flow and structure. Multivariate regression analysis revealed that reduced blood flow and structural loss are independent predictors of visual field loss. Each dB decrease in blood flow was associated with at least 1.62 dB loss in mean deviation (P ≤ 0.001), whereas each dB decrease in rim area and RNFL was associated with 1.15 dB and 2.56 dB loss in mean deviation, respectively (P ≤ 0.03).
Conclusions. There is a close link between reduced retinal blood flow and visual field loss in glaucoma that is largely independent of structural loss. Further studies are needed to elucidate the causes of the vascular dysfunction and potential avenues for therapeutic intervention. Blood flow measurement may be useful as an independent assessment of glaucoma severity.
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