December 1966
Volume 5, Issue 6
Free
Articles  |   December 1966
Autoradiographic studies on the growth and development of the lens capsule in the rat
Author Affiliations
  • RICHARD W. YOUNG
    Department of Anatomy, University of California at Los Angeles, School of Medicine Los Angeles, Calif.
  • DAVID E. OCUMPAUGH
    Department of Anatomy, University of California at Los Angeles, School of Medicine Los Angeles, Calif.
Investigative Ophthalmology & Visual Science December 1966, Vol.5, 583-593. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      RICHARD W. YOUNG, DAVID E. OCUMPAUGH; Autoradiographic studies on the growth and development of the lens capsule in the rat. Invest. Ophthalmol. Vis. Sci. 1966;5(6):583-593.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Growth of the rat lens capsule was analyzed by autoradiography, following injection of 35S-sulfate or 3H-glycine. Although growth was most rapid in young animals, it continued well into adulthood, accompanied by the development of increasing regional variations in thickness. Capsular labeling with both precursors paralleled these dimensional changes, being highest in young animals and greater in regions which thickened most rapidly, with one exception: 35S-sulfate was heavily incorporated into the capsule at the site of attachment of the suspensory ligament, which was not a site of preferential thickening. A strong staining reaction for acid mucopolysaccharides was obtained in this zone, suggesting that the localized concentration of 35S may reflect a regional difference in composition of the capsule. The labeled precursors were initially incorporated by the superficial cells of the lens, and subsequently transferred to the capsule, indicating that the capsule was a product of the subjacent cells. Thickening of the capsule gradually displaced the radioactivity outward, away from the cells, due to the deposition of new capstdar material on the inner surface. This lamellar mode of apposition may be related to the lamellated fine structure of the capside

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×