December 1966
Volume 5, Issue 6
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Articles  |   December 1966
Antagonists of DNA synthesis in corneal epithelial cells of the dogfish
Author Affiliations
  • Seymour Zigman
    Department of Surgery, Division of Ophthalmology, and Department of Biochemistry, University of Rochester School of Medicine and Dentistry Rochester, N.Y.
  • Joan Tuttle
    Department of Surgery, Division of Ophthalmology, and Department of Biochemistry, University of Rochester School of Medicine and Dentistry Rochester, N.Y.
  • Sidney Lerman
    Department of Surgery, Division of Ophthalmology, and Department of Biochemistry, University of Rochester School of Medicine and Dentistry Rochester, N.Y.
Investigative Ophthalmology & Visual Science December 1966, Vol.5, 636-639. doi:
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      Seymour Zigman, Joan Tuttle, Sidney Lerman; Antagonists of DNA synthesis in corneal epithelial cells of the dogfish. Invest. Ophthalmol. Vis. Sci. 1966;5(6):636-639.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The epithelial cells of the cornea of the dogfish continue to incorporate thymidine into their DNA during incubation in elasmobranch Ringer's solutions under appropriate conditions. This incorporation of H3 thymidine can be markedly inhibited by including IUDR in the medium, or by preirradiation of the cells with gamma rays or UV light

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