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W. W. OPPELT, E. D. WHITE; Effect of Ouabain on Aqueous Humor Formation Rate in Cats. Invest. Ophthalmol. Vis. Sci. 1968;7(3):328-333.
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The effect of intravenous and intracameral ouabain on aqueous humor (AH) formation rates was measured in cats. AH formation rate was determined with continuous, posteroanterior chamber perfusion with an AH-like buffer containing trace quantities of inulin-C14. After intravenous injection of 67 µg of ouabain per kilogram, there was a 40 per cent reduction in AH formation rate, while 34 µg per kilogram caused a 26 per cent reduction. There was no change after 10 µg of intravenous ouabain per kilogram. In other experiments, ouabain-containing buffer was substituted for the control buffer after a control period. No change in AH formation rates was noted after intracameral perfusion with 10-4M, 10-6M, or 10-8M ouabain. It is concluded that high doses of intravenous ouabain significantly decrease AH formation rates, probably by inhibition of ciliary body Na-K activated adenosine triphosphatase. There is no effect on AH formation rates by high and low doses of intracameral ouabain.
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