August 1969
Volume 8, Issue 4
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Articles  |   August 1969
Antibody Formation by Single Cells during Experimental Immunogenic Uveitis
Author Affiliations
  • RONALD E. SMITH
    The Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Md.
  • ALLAN D. JENSEN
    The Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Md.
  • ARTHUR M. SILVERSTEIN
    The Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Md.
Investigative Ophthalmology & Visual Science August 1969, Vol.8, 373-380. doi:
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    • Get Citation

      RONALD E. SMITH, ALLAN D. JENSEN, ARTHUR M. SILVERSTEIN; Antibody Formation by Single Cells during Experimental Immunogenic Uveitis. Invest. Ophthalmol. Vis. Sci. 1969;8(4):373-380.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The Jerne plaquing technique for the demonstration of single antibody-forming cells was employed to study the kinetics of the antibody response that accompanies experimental immunogenic uveitis in rabbits produced by intravitreal injection of sheep erythrocyte stromas. Prior to the onset of uveitis, a modest increase in antibody formation in the spleen can be detected. With the appearance of uveitis, the proportion in the uveal tract of inflammatory cells that form antibody rapidlyincreases, reaches a peak at about the tenth day, and then slowly declines; 150 days after clinical uveitis has subsided, no antibody-forming cells can be found in the uveal tract. The role of ocular antibody formation in the pathogenesis of recurrent uveitis is discussed.

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