August 1969
Volume 8, Issue 4
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Articles  |   August 1969
Effects of Phenylephrine, Butylsympatol, Pilocarpine, and Lithium on Runout of 86Rb from Isolated Rabbit Ciliary Processes
Author Affiliations
  • JANET VALE
    Department of Pharmacology, University of Uppsala, Uppsala, Sweden
  • ERNST H. BÁRÁny
    Department of Pharmacology, University of Uppsala, Uppsala, Sweden
Investigative Ophthalmology & Visual Science August 1969, Vol.8, 422-433. doi:
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      JANET VALE, ERNST H. BÁRÁny; Effects of Phenylephrine, Butylsympatol, Pilocarpine, and Lithium on Runout of 86Rb from Isolated Rabbit Ciliary Processes. Invest. Ophthalmol. Vis. Sci. 1969;8(4):422-433.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Isolated ciliary processes from pigmented rabbits were incubated with 86Rb, washed, and transferred to a runout medium. The appearance of 86Rb in this medium was followed. Uptake of 86Rb is decreased by lack of glucose and/or oxygen, and by 10 times excess potassium. Runout is decreased by cold (+10° C.) and by 3 or 30 mM. Ca and increased by complete substitution of lithium for sodium. Pilocarpine (10-3, 10-5M) had a small accelerating effect limited to the initial phase of runout, while the stable B-adrenergicagent butylsympatol (10-3M) in the presence of 2 mM. Ca had a very small but more longlasting accelerating effect. The a-adrenergic phenylephrine (10-2M) had no effect.

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