October 1969
Volume 8, Issue 5
Free
Articles  |   October 1969
Effect of Alloxan Diabetes on the Fatty Acid Composition of the Retina
Author Affiliations
  • SIDNEY FUTTERMAN
    Department of Ophthalmology, University of Washington Medical School, Seattle, Wash. 98105
  • RONALD STURTEVANT
    Department of Ophthalmology, University of Washington Medical School, Seattle, Wash. 98105
  • CARL KUPFER
    Department of Ophthalmology, University of Washington Medical School, Seattle, Wash. 98105
Investigative Ophthalmology & Visual Science October 1969, Vol.8, 542-544. doi:
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      SIDNEY FUTTERMAN, RONALD STURTEVANT, CARL KUPFER; Effect of Alloxan Diabetes on the Fatty Acid Composition of the Retina. Invest. Ophthalmol. Vis. Sci. 1969;8(5):542-544.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The fatty acid composition of untreated alloxan-diabetic and normal rat retinal tissue was compared and the relative abundance of endothelial and mural cells in the retinal capillaries was estimated. Arachidonate and docosahexaenoate were decreased in diabetic retinal tissue; linoleate was increased. The changes observed indicate that insulin is required to maintain a normal rate of polyenoic fatty acid synthesis in retinal tissue. No selective loss of mural cells from the retinal capillaries could be found.

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