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STEPHEN R. WALTMAN, TULLY C. PATROWICZ; Effects of Hydroxypropyl Methylcellulose and Polyvinyl Alcohol on Intraocular Penetration of Topical Fluorescein in Man. Invest. Ophthalmol. Vis. Sci. 1970;9(12):966-970.
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A slit lamp fluorophotometer was used to measure penetration of topical 2 per cent fluorescein, in various vehicles, into human eyes. The technique provides a sensitive method for measuring attained fluorescein concentrations in the anterior segment of the eye. One-half per cent hydroxypropyl methylcellulose significantly increased the penetration of the drug as compared to penetration with 1.4 per cent polyvinyl alcohol or aqueous solutions. Doubling the concentration of fluorescein in the vehicles doubled the attained intraocular concentrations. Very little of the applied drug penetrated into the anterior segment.
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