June 1969
Volume 8, Issue 3
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Articles  |   June 1969
Recurrence of Herpes Simplex Virus Vin Rabbit Eyes: Results of a Three-Year Study
Author Affiliations
  • PETER R. LAIBSON
    Cornea Service, Wills Eye Hospital and Research Institute of Temple University Medical Center Philadelphia, Pa., Evans Memorial Department of Clinical Research, University Hospital, and the Departments of Microbiology and Medicine, Boston University School of Medicine, Boston University Medical Center
  • SIDNEY KIBRICK
    Cornea Service, Wills Eye Hospital and Research Institute of Temple University Medical Center Philadelphia, Pa., Evans Memorial Department of Clinical Research, University Hospital, Departments of Microbiology and Medicine, Boston University School of Medicine, Boston University Medical Center
Investigative Ophthalmology & Visual Science June 1969, Vol.8, 346-350. doi:
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      PETER R. LAIBSON, SIDNEY KIBRICK; Recurrence of Herpes Simplex Virus Vin Rabbit Eyes: Results of a Three-Year Study. Invest. Ophthalmol. Vis. Sci. 1969;8(3):346-350.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Spontaneous reactivation of herpes simplex virus in rabbit ocular tissue was found on 112 occasions in 50 rabbits for up to 3 years after the primary eye infection. To detect these spontaneous reappearances of virus, cultures for herpes simplex virus were obtained 5 or 6 days a week from the cul-de-sac of rabbit eyes for various periods up to 3 years. Keratitis was also intermittently observed but 72 per cent of the viral reactivations occurred without coincidental corneal disease. Once the rabbit eye is infected with herpes simplex virus a chronic inapparent infection ensues which probably persists for the life of the animal.

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