February 1970
Volume 9, Issue 2
Free
Articles  |   February 1970
A Comparison of Corneal Epithelium Regeneration in Normal and Buphthalmic Rabbits
Author Affiliations
  • THOMAS M. HARRIS
    Departments of Anatomy and Ophthalmology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Va., The Jackson Laboratory, Bar Harbor, Maine
  • L. BENJAMIN SHEPPARD
    Departments of Anatomy and Ophthalmology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Va., The Jackson Laboratory, Bar Harbor, Maine
  • WILLIAM M. SHANKLIN
    Departments of Anatomy and Ophthalmology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Va., The Jackson Laboratory, Bar Harbor, Maine
  • RICHARD R. FOX
    Departments of Anatomy and Ophthalmology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Va., The Jackson Laboratory, Bar Harbor, Maine
Investigative Ophthalmology & Visual Science February 1970, Vol.9, 122-130. doi:
  • Views
  • PDF
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      THOMAS M. HARRIS, L. BENJAMIN SHEPPARD, WILLIAM M. SHANKLIN, RICHARD R. FOX; A Comparison of Corneal Epithelium Regeneration in Normal and Buphthalmic Rabbits. Invest. Ophthalmol. Vis. Sci. 1970;9(2):122-130.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

A large globe and corneal clouding form an early finding in infantile buphthalmia in both rabbits and human subjects which is frequently associated with fragility and sloughing of the corneal epithelium. The severity of the lesions increases with the severity of the buphthalmia. This study was designed to determine comparatively if the severity of buphthalmia is reflected in the ability of corneal epithelium to regenerate. The epithelium was scraped from 34 rabbit corneas representing five categories of eyes: two normal groups and three buphthalmic. The daily rate of epithelial regeneration was calculated by planimetric measurements taken from enlarged photographs of fluorescein-stained eyes. The actual area of corneal epithelium regenerated daily by each eye is presented in tabular form. When these data were subjected to statistical analysis it was found that in rabbit eyes there is no relation between the severity of buphthalmia and the ability of the eye to regenerate corneal epithelium. Extremely buphthalmic eyes can regenerate as efficiently as the eyes of genetically normal animals from the same colony. There does appear to be a direct relation between the severity of the buphthalmia and the looseness of the regenerated epithelium. It is proposed that this looseness of the buphthalmic corneal epithelium may be related to a deficiency in the basement membrane.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×