April 1970
Volume 9, Issue 4
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Articles  |   April 1970
Ocular Infection of Rabbits With a Bedsonia Isolated from a Patient With Reiter's Syndrome
Author Affiliations
  • BRUCE H. OSTLER
    Francis I. Proctor Foundation for Research in Ophthalmology and the George Williams Hooper Foundation, Universityof California, San Francisco Medical Center, San Francisco, Calif.
  • JULIUS SCHACHTER
    Francis I. Proctor Foundation for Research in Ophthalmology and the George Williams Hooper Foundation, Universityof California, San Francisco Medical Center, San Francisco, Calif.
  • CHANDLER R. DAWSON
    Francis I. Proctor Foundation for Research in Ophthalmology and the George Williams Hooper Foundation, Universityof California, San Francisco Medical Center, San Francisco, Calif.
Investigative Ophthalmology & Visual Science April 1970, Vol.9, 256-262. doi:
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      BRUCE H. OSTLER, JULIUS SCHACHTER, CHANDLER R. DAWSON; Ocular Infection of Rabbits With a Bedsonia Isolated from a Patient With Reiter's Syndrome. Invest. Ophthalmol. Vis. Sci. 1970;9(4):256-262.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Eye disease, consisting of a papillary conjunctivitis, corneal edema, corneal opactiy, corneal neovascularization, and iritis, was readily produced in New Zealand white rabbits by the intracameral inoculation of a Bedsonia recovered from the synovial membrane of a patient with Reiter's syndrome. No eye disease could be produced by the instillation of the agent into the rabbit's conjunctival sac. The agent was found to persist in the conjunctiva for at least 23 days and in the anterior chamber for at least 68 days. It spread to the liver, lung, spleen, and joints. Arthritis was noted in one of 6 rabbits inoculated conjunctivally and in 2 of 8 rabbits inoculated with high titers of the agent intracamerally. In one rabbit in each of these groups, behavior indicating central nervous system changes was also noted.

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