September 1970
Volume 9, Issue 9
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Articles  |   September 1970
The Influence of Polyinosinic-Polycytidylic Acid Complex on Vaccinia Keratitis in Rabbits
Author Affiliations
  • ENDLIAM CHOWCHUVECH
    Department of Ophthalmology of the New York Medical College, New York, N. Y. and the United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
  • MERCEDES WEISSENBACHER
    Department of Ophthalmology of the New York Medical College, New York, N. Y. and the United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
  • MILES A. GALIN
    Department of Ophthalmology of the New York Medical College, New York, N. Y. and the United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
  • SAMUEL BARON
    Department of Ophthalmology of the New York Medical College, New York, N. Y. and the United States Department of Health, Education and Welfare, National Institute of Allergy and Infectious Diseases, Laboratory of Viral Diseases, Bethesda, Md.
Investigative Ophthalmology & Visual Science September 1970, Vol.9, 716-721. doi:
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      ENDLIAM CHOWCHUVECH, MERCEDES WEISSENBACHER, MILES A. GALIN, SAMUEL BARON; The Influence of Polyinosinic-Polycytidylic Acid Complex on Vaccinia Keratitis in Rabbits. Invest. Ophthalmol. Vis. Sci. 1970;9(9):716-721.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Topical polyinosinic-polycytidylic acid complex was used prophylactically and therapeutically in experimental vaccinia keratitis of rabbits. It was found that this interferon inducer protects against vaccinia infection when administered from three days up to eight hours before infection. Its therapeutic efficacy diminished with time and was absent 24 hours after infection.

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