April 1970
Volume 9, Issue 4
Free
Articles  |   April 1970
The Complement Components and their Inactivators in the Intraocular Fluids of the Guinea Pig
Author Affiliations
  • KOHKICHI SHIMADA
    Department of Ophthalmology, University of Tokyo School of Medicine, Hongo, Tokyo, Japan; Virology Division, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan
Investigative Ophthalmology & Visual Science April 1970, Vol.9, 307-315. doi:
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      KOHKICHI SHIMADA; The Complement Components and their Inactivators in the Intraocular Fluids of the Guinea Pig. Invest. Ophthalmol. Vis. Sci. 1970;9(4):307-315.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

The first component of complement was not detectable in the normal intraocular fluids of the guinea pig, whereas 8 other components were found to be present at extremely low titer. On the contrary, it was shown that the complement inactivators are at high concentrations. In the secondary aqueous following paracentesis, titers of the complement inactivators and components except C1 increased nearly to the serum level. The C1 activity became detectable in the secondary aqueous but its level was only 1/200 of the serum level. These complement titers gradually returned to a normal level in a week's time, while C1 activity disappeared rapidly within 3 days.

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