August 2014
Volume 55, Issue 8
Free
Letters to the Editor  |   August 2014
Glaucoma Considered as an Imbalance Between Production and Clearance of Neurotoxins
Author Affiliations & Notes
  • Diya Yang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
  • Jidi Fu
    Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
  • Ruowu Hou
    Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
  • Kegao Liu
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
  • Jost B. Jonas
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany;
  • Huaizhou Wang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
  • Weiwei Chen
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
  • Zhen Li
    Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China;
  • Jinghong Sang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
  • Zheng Zhang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
  • Sumeng Liu
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
  • Yiwen Cao
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
  • Xiaobin Xie
    Department of Ophthalmology, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China; and
  • Ruojin Ren
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
  • Qingjun Lu
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
  • Robert N. Weinreb
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, California, United States.
  • Ningli Wang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China;
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China;
Investigative Ophthalmology & Visual Science August 2014, Vol.55, 5353. doi:10.1167/iovs.14-15244
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    • Get Citation

      Diya Yang, Jidi Fu, Ruowu Hou, Kegao Liu, Jost B. Jonas, Huaizhou Wang, Weiwei Chen, Zhen Li, Jinghong Sang, Zheng Zhang, Sumeng Liu, Yiwen Cao, Xiaobin Xie, Ruojin Ren, Qingjun Lu, Robert N. Weinreb, Ningli Wang; Glaucoma Considered as an Imbalance Between Production and Clearance of Neurotoxins. Invest. Ophthalmol. Vis. Sci. 2014;55(8):5353. doi: 10.1167/iovs.14-15244.

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      © ARVO (1962-2015); The Authors (2016-present)

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  • Supplements
We thank Wostyn and colleagues 1 for their interest in our study, 2 and we fully agree that a change in the circulation of the orbital cerebrospinal fluid with consequences on the turnover and composition of the cerebrospinal fluid may be one of the reasons, which could explain why two out of the four monkeys of the study group did not develop optic nerve damage. 3  
References
Wostyn P De Groot V Van Dam D Audenaert K Killer HE De Deyn PP. Glaucoma considered as an imbalance between production and clearance of neurotoxins. Invest Ophthalmol Vis Sci . 2014; 55: 5351–5352. [CrossRef] [PubMed]
Yang D Fu J Hou R Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys. Invest Ophthalmol Vis Sci . 2014; 55: 3067–3073. [CrossRef] [PubMed]
Killer HE Miller NR Flammer J Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma. Br J Ophthalmol . 2012; 96: 544–548. [CrossRef] [PubMed]
Footnotes
 Open Access Article: No
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