June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
New Advancements to High-Density Packaging Technology for the Boston Retinal Prosthesis
Author Affiliations & Notes
  • Douglas Shire
    Research - Vision, VA Healthcare System, Boston, MA
    NanoScale Science and Technology Facility, Cornell University, Ithaca, NY
  • Thomas Salzer
    Proprietor, Hermetric, Inc., Bedford, MA
  • William Jones
    Advanced Materials Engineering Research Institute, Florida International University, Miami, FL
  • Ali Karbasi
    Advanced Materials Engineering Research Institute, Florida International University, Miami, FL
  • Oscar Mendoza
    Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA
  • Shawn Kelly
    Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA
  • John Wyatt
    Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA
  • Joseph Rizzo
    Neuro-Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA
  • Footnotes
    Commercial Relationships Douglas Shire, VA CIVR (P); Thomas Salzer, Hermetric, Inc. (C); William Jones, None; Ali Karbasi, None; Oscar Mendoza, None; Shawn Kelly, Bionic Eye Technologies (P); John Wyatt, Bionic Eye, Ltd. (P); Joseph Rizzo, Bionic Eye Technology (I), Bionic Eye Technology (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1048. doi:
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    • Get Citation

      Douglas Shire, Thomas Salzer, William Jones, Ali Karbasi, Oscar Mendoza, Shawn Kelly, John Wyatt, Joseph Rizzo, ; New Advancements to High-Density Packaging Technology for the Boston Retinal Prosthesis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1048.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

This work is related to the efforts of the Boston Retinal Implant Project to develop a sub-retinal prosthesis to restore vision to the blind. We present new high density packaging advancements for the Boston prosthesis, and bonding processes for the exterior of the packages.

 
Methods
 

Co-fired ceramic structures with signal feedthroughs formed from a platinum-rhodium alloy were fabricated to mate with hermetic packages for the retinal implant; feedthrough discs were gold brazed to the miniature titanium housings. In subsequent assembly steps, flexible electrode arrays with electroplated gold contact pads were joined to the feedthrough assemblies by thermo-compression bonding. A custom fixture for making temporary contact to the bonded prostheses for testing purposes was designed and built, which allowed the bonded devices to be wirelessly tested before affixing the protective headers.

 
Results
 

Tests of the retinal implant assemblies' quality were performed by helium leak testing and bond pull tests. In the Figures, the co-fired ceramic discs and the bonded prosthesis assemblies are shown. When thermo-compression bonds to the prosthesis' iridium oxide electrode arrays were performed at 150 degrees C had an average shear strength of more than 50 grams force, indicating good quality bonding. Room temperature bonds were markedly weaker. Helium leak rates better than 1.0x10E-09 standard cc He / second were measured. The completed assemblies were extensively tested wirelessly in vitro and can monitor individual electrode voltage waveforms via on-chip analog to digital converters.

 
Conclusions
 

Improved feedthrough fabrication and bonding methods to miniature implantable titanium retinal prosthesis assemblies have been demonstrated, and completed retinal implants having 256+ channels were successfully tested wirelessly. These results pave the way for clinical testing of the Boston retinal prosthesis in the near future.

 
 
A high-density co-fired ceramic disc for the Boston Retinal Prosthesis, prior to hermetic sealing and bonding of the electrode array.
 
A high-density co-fired ceramic disc for the Boston Retinal Prosthesis, prior to hermetic sealing and bonding of the electrode array.
 
 
Flexible electrode Array for the high-density Boston Retinal Prosthesis bonded to the exterior of the ceramic feedthrough disc, prior to attachment of the protective header.
 
Flexible electrode Array for the high-density Boston Retinal Prosthesis bonded to the exterior of the ceramic feedthrough disc, prior to attachment of the protective header.
 
Keywords: 688 retina • 412 age-related macular degeneration • 669 quality of life  
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