June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
In vivo evaluation of the liquid crystal polymer-based retinal prosthesis by optical coherence tomography
Author Affiliations & Notes
  • Hum Chung
    Ophthalmology, Seoul National University, Seoul, Republic of Korea
  • Bum-Joo Cho
    Ophthalmology, Seoul National University, Seoul, Republic of Korea
  • Hee Sun Park
    Ophthalmology, Seoul National University, Seoul, Republic of Korea
  • So Hyun Bae
    Ophthalmology, Seoul National University, Seoul, Republic of Korea
    Ophthalmology, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea
  • Tae Wan Kim
    Ophthalmology, Seoul National University, Seoul, Republic of Korea
    Ophthalmology, Seoul Nat'l Univ Boramae Medical Ctr, Seoul, Republic of Korea
  • Jong-Mo Seo
    Ophthalmology, Seoul National University, Seoul, Republic of Korea
    Electrical Engineering, Seoul National University, Seoul, Republic of Korea
  • Hyeong Gon Yu
    Ophthalmology, Seoul National University, Seoul, Republic of Korea
  • Joonsoo Jeong
    Electrical Engineering, Seoul National University, Seoul, Republic of Korea
  • Soowon Shin
    Electrical Engineering, Seoul National University, Seoul, Republic of Korea
  • Sung June Kim
    Electrical Engineering, Seoul National University, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships Hum Chung, None; Bum-Joo Cho, None; Hee Sun Park, None; So Hyun Bae, None; Tae Wan Kim, None; Jong-Mo Seo, None; Hyeong Gon Yu, None; Joonsoo Jeong, None; Soowon Shin, None; Sung June Kim, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1062. doi:
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    • Get Citation

      Hum Chung, Bum-Joo Cho, Hee Sun Park, So Hyun Bae, Tae Wan Kim, Jong-Mo Seo, Hyeong Gon Yu, Joonsoo Jeong, Soowon Shin, Sung June Kim; In vivo evaluation of the liquid crystal polymer-based retinal prosthesis by optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1062.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Liquid crystal polymer (LCP) - based, monolithic retinal prosthesis was developed, and in vivo biocompatibility and biostability were evaluated in the rabbit eye by using optical coherent tomography (OCT).

Methods: LCP-based gold electrode array was fabricated and the electrical retinal stimulator was integrated into the LCP package to form a monolithic prosthesis system. After making scleral tunnel in the rabbit eye, electrode part was implanted suprachoroidally or subretinally, and the stimulator package was positioned and fixed over the sclera, in the sub-tenon space. Regular post-operative evaluation was done by OCT, fundus photography and electroretinography (ERG).

Results: OCT showed the chorioretinal structure over the electrodes in detail. However, LCP was opaque to the light, thus there were shadows under the electrodes. This made the choroidal evaluation difficult in the eye with subretinal LCP electrode. Localized tenting or stretching of the retina or choroid over the electrode was well visualized by OCT, and this could not be identified easily on the fundus photograph. Some structural changes of the retina over the LCP electrodes were found in 7 out of 14 eyes, and these might be due to the intraoperative surgical events, not due to the toxicity of the LCP itself. ERG waveform was correlated with the change on the OCT finding.

Conclusions: LCP retinal prosthesis showed good in vivo biocompatibility and biostability. OCT was useful for the evaluation of anatomical and histological outcome of LCP retinal prosthesis implantation and the physical characteristics of the LCP implants.

Keywords: 688 retina • 741 transplantation  
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