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Hum Chung, Bum-Joo Cho, Hee Sun Park, So Hyun Bae, Tae Wan Kim, Jong-Mo Seo, Hyeong Gon Yu, Joonsoo Jeong, Soowon Shin, Sung June Kim; In vivo evaluation of the liquid crystal polymer-based retinal prosthesis by optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1062.
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© ARVO (1962-2015); The Authors (2016-present)
Liquid crystal polymer (LCP) - based, monolithic retinal prosthesis was developed, and in vivo biocompatibility and biostability were evaluated in the rabbit eye by using optical coherent tomography (OCT).
LCP-based gold electrode array was fabricated and the electrical retinal stimulator was integrated into the LCP package to form a monolithic prosthesis system. After making scleral tunnel in the rabbit eye, electrode part was implanted suprachoroidally or subretinally, and the stimulator package was positioned and fixed over the sclera, in the sub-tenon space. Regular post-operative evaluation was done by OCT, fundus photography and electroretinography (ERG).
OCT showed the chorioretinal structure over the electrodes in detail. However, LCP was opaque to the light, thus there were shadows under the electrodes. This made the choroidal evaluation difficult in the eye with subretinal LCP electrode. Localized tenting or stretching of the retina or choroid over the electrode was well visualized by OCT, and this could not be identified easily on the fundus photograph. Some structural changes of the retina over the LCP electrodes were found in 7 out of 14 eyes, and these might be due to the intraoperative surgical events, not due to the toxicity of the LCP itself. ERG waveform was correlated with the change on the OCT finding.
LCP retinal prosthesis showed good in vivo biocompatibility and biostability. OCT was useful for the evaluation of anatomical and histological outcome of LCP retinal prosthesis implantation and the physical characteristics of the LCP implants.
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