June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Systemic factors impacting intraocular levels of vascular endothelial growth factor and interleukin-6 in diabetic retinopathy
Author Affiliations & Notes
  • Sohee Jeon
    Ophthalmology, Seoul Saint Mary's hospital, Seoul, Republic of Korea
  • Won Ki Lee
    Ophthalmology, Seoul Saint Mary's hospital, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships Sohee Jeon, None; Won Ki Lee, Novartis (F), Novartis (C), Bayer (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 107. doi:
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      Sohee Jeon, Won Ki Lee; Systemic factors impacting intraocular levels of vascular endothelial growth factor and interleukin-6 in diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):107.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To identify systemic factors correlating with intraocular levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in diabetic retinopathy (DR).

Methods: This study was a cross-sectional study. Forty-two consecutive patients (42 eyes) undergoing pars plana vitrectomy (PPV) for DR were enrolled. Aqueous humor was sampled just prior to PPV for assay of IL-6 and VEGF via multiplex cytokine array. One day before PPV, patient characteristics (age, gender, duration of diabetes, body mass index [BMI], systolic and diastolic blood pressure, alcohol, and smoking status) were recorded and a number of systemic markers amassed, including fasting and postprandial glucose, homeostasis model assessment (HOMA)-IR, HOMA-beta, C-peptide, insulin, total cholesterol, triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, apolipoprotein (Apo)-A, Apo-B, and lipoprotein A (Lp-A). Relationships between systemic determinants and intraocular cytokine levels (IL-6 and VEGF) were analyzed by univariate and multivariate regression.

Results: Median levels of IL-6 and VEGF were 15.3 pg/mL (range, 2.4-10124.5 pg/mL) and 21.1 pg/mL (range, 3.2-766.1 pg/mL), respectively. After adjustment for age, gender, duration of diabetes, and BMI, multivariate analysis showed significant association of smoking (p=0.002) and HOMA-IR (p=0.003) with intraocular IL-6 levels, while intraocular VEGF and systemic Lp-A levels correlated significantly (p=0.032).

Conclusions: Insulin resistance (HOMA-IR) and smoking status impacted intraocular levels of IL-6, while intraocular VEGF levels were influenced by Lp-A. An appreciation for the relationship between systemic factors and intraocular level of various cytokines may help elucidate the complex pathophysiology of DR.

Keywords: 499 diabetic retinopathy • 490 cytokines/chemokines • 748 vascular endothelial growth factor  
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