June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
The Incidence of Curvularia Keratitis and A Case Series of Curvularia Endophthalmitis
Author Affiliations & Notes
  • Ashvini Reddy
    Ophthalmology, Bascom Palmer / University of Miami, Miami, FL
  • Aleksandra Rachitskaya
    Ophthalmology, Bascom Palmer / University of Miami, Miami, FL
  • Darlene Miller
    Ophthalmology, Bascom Palmer / University of Miami, Miami, FL
  • Harry Flynn
    Ophthalmology, Bascom Palmer / University of Miami, Miami, FL
  • William Smiddy
    Ophthalmology, Bascom Palmer / University of Miami, Miami, FL
  • Wilfredo Lara
    Retina Specialists of South Florida, Miami, FL
  • Thomas Albini
    Ophthalmology, Bascom Palmer / University of Miami, Miami, FL
  • Footnotes
    Commercial Relationships Ashvini Reddy, None; Aleksandra Rachitskaya, None; Darlene Miller, None; Harry Flynn, None; William Smiddy, None; Wilfredo Lara, None; Thomas Albini, Bausch and Lomb (C), Allergan (C), Genentech (F), Eleven Biotherapeutics (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1102. doi:
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      Ashvini Reddy, Aleksandra Rachitskaya, Darlene Miller, Harry Flynn, William Smiddy, Wilfredo Lara, Thomas Albini; The Incidence of Curvularia Keratitis and A Case Series of Curvularia Endophthalmitis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1102.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To report a case series of Curvularia endophthalmitis and to determine the number of Curvularia positive corneal cultures at a single academic center in five year increments from January 1, 1980 to October 17, 2012.

 
Methods
 

Retrospective review of Bascom Palmer Eye Institute microbiology archives and patient charts for demographic information, clinical features, etiology, treatment, and outcomes in Curvularia endophthalmitis. The number of corneal cultures positive for Curvularia in five year increments was determined.

 
Results
 

Seven adult patients with exogenous Curvularia endophthalmitis (4 post-operative, 3 posttraumatic) were seen between 1980 and 2012. In 3 cases the endophthalmitis followed trauma. In 4 postoperative cases, patients became symptomatic 2-5 months following surgery and the time to definitive diagnosis ranged from 7-19 months. In post-operative cases, successful treatment was achieved 8-25 months following the original surgery and often required surgical removal of an infectious nidus, in addition to the lens capsule. When assessed by five-year increments, the number of Curvularia keratitis cases increased over the study period. No cases of Curvularia keratitis were seen between 1980 and 1984, while 30 cases were seen between 2005 and 2009.

 
Conclusions
 

The incidence of Curvuleria keratitis increased from 1980 to 2009 in an academic center. In postoperative endophthalmitis cases, patients typically present with chronic inflammation and the diagnosis requires a high index of suspicion as it can be difficult to establish. Definitive treatment often requires removal of an infectious nidus, in addition to removal of the lens capsule.

 
Keywords: 513 endophthalmitis • 530 fungal disease • 573 keratitis  
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