June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Associations of Serum Lipids with Macular Morphology in Patients without Diabetic Macular Edema
Author Affiliations & Notes
  • Mariko Sasaki
    Ophthalmology, Keio University, Tokyo, Japan
    Ophthalmology, Melbourne University, Melbourne, VIC, Australia
  • Motoko Kawashima
    Ophthalmology, Keio University, Tokyo, Japan
  • Ryo Kawasaki
    Ophthalmology, Melbourne University, Melbourne, VIC, Australia
    public health, Yamagata University, yamagata, Japan
  • Miho Kawai
    Ophthalmology, Keio University, Tokyo, Japan
  • Atsuro Uchida
    Ophthalmology, Keio University, Tokyo, Japan
  • Takashi Koto
    Ophthalmology, Keio University, Tokyo, Japan
  • Hajime Shinoda
    Ophthalmology, Keio University, Tokyo, Japan
  • Kazuo Tsubota
    Ophthalmology, Keio University, Tokyo, Japan
  • Jie Wang
    Ophthalmology, Melbourne University, Melbourne, VIC, Australia
    Ophthalmology, University of Sydney, Sydney, NSW, Australia
  • Yoko Ozawa
    Ophthalmology, Keio University, Tokyo, Japan
  • Footnotes
    Commercial Relationships Mariko Sasaki, None; Motoko Kawashima, Santen Pharmaceutical Co., Ltd (F); Ryo Kawasaki, None; Miho Kawai, None; Atsuro Uchida, None; Takashi Koto, None; Hajime Shinoda, None; Kazuo Tsubota, AcuFocus, Inc (C), Allergan (F), Bausch Lomb Surgical (C), Functional visual acuity meter (P), JiNS (P), Kissei (F), Kowa (F), Santen, Inc. (F), Otsuka (F), Pfizer (C), Thea (C), Echo Denki (P), Nidek (F), Ophtecs (F), Wakasa Seikatsu (F), CEPT Company (P); Jie Wang, None; Yoko Ozawa, Wakasa Seikatsu.Co.,Ltd. (F), NOVARTIS Pharmacetutical Co., Ltd (F), Senju Pharmaceutical Co., Ltd. (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1237. doi:
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      Mariko Sasaki, Motoko Kawashima, Ryo Kawasaki, Miho Kawai, Atsuro Uchida, Takashi Koto, Hajime Shinoda, Kazuo Tsubota, Jie Wang, Yoko Ozawa; Associations of Serum Lipids with Macular Morphology in Patients without Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1237.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: This study aims to assess optical coherence tomography (OCT) measured macular morphological parameters in diabetic patients without or with minimal diabetic retinopathy (DR) but no macular edema (DME), and their associations with known DR risk factors.

Methods: Cross-sectional data were collected from 76 patients with diabetes and without DME (70 without DR and 6 with minimum DR), who were recruited at a tertiary eye hospital in Tokyo. Minimum foveal thickness (MFT; μm), central macular thickness (CMT; Circle of 500μm radius; μm) and foveal volume (FV; mm3) were measured using spectral domain OCT (Heidelberg Spectralis SDOCT, Heidelberg Engineering, Germany). Associations between the three OCT measures and known risk factors of DR were examined using multiple linear regression models.

Results: Of 76 participants with good quality OCT and fundus images (mean age 59.2 years), MFT, CMT and FV in their right eyes were 220.7 μm±17.2, 273.5 μm ± 17.6 and 0.215± 0.014 mm3, respectively. After adjusted for age, gender, hemoglobin A1c, and urine protein, Higher level of Low-Density Lipoprotein (LDL) cholesterol was associated with increased MFT ( per 10 mmol/L increase in LDL, mean change in MFT: 1.463μm, 95% CI: 0.215 to 2.711), CMT ( per 10 mmol/L increase, mean change in CMT: 1.543μm, 95% CI: 0.379 to 2.706) and FV ( per 10 mmol/L increase, mean change in FV: 0.001 mm3, 95% CI: 1.402E-4 to 0.002).

Conclusions: We found that higher LDL cholesterol levels were associated with increased macular thickness and foveal volumes in this patient sample. These associations are in keeping with the associations between serum LDL levels with clinical DME. Further studies are needed to understand whether macular morphological parameters in patients with diabetes without DME are associated with future risk of developing clinical DME, and reveal the clinical implication of these findings.

Keywords: 498 diabetes • 499 diabetic retinopathy • 505 edema  
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