June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Optical Coherence Tomography of the Optic Nerve: Comparison Between Multiple Sclerosis and Neuromyelitis Optica
Author Affiliations & Notes
  • Lucas Daniel Fernandes
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
  • Phelipe Paixao
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias da Saude, Universidade Federal do Para, Belem, Brazil
  • Lorena Botelho Vergara
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
  • Juliana Araujo
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Faculdade de Medicina, Centro Universitario do Para, Belem, Brazil
  • Eliza Maria Lacerda
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
  • Givago Souza
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
  • Hideraldo Luis Souza Cabeça
    Hospital Ophir Loyola, Belem, Brazil
  • Alexandre Rosa
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Hospital Universitario Bettina Ferro de Souza, Universidade Federal do Para, Belem, Brazil
  • Luiz Carlos Silveira
    Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Brazil
    Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem, Brazil
  • Footnotes
    Commercial Relationships Lucas Daniel Fernandes, None; Phelipe Paixao, None; Lorena Botelho Vergara, None; Juliana Araujo, None; Eliza Maria Lacerda, None; Givago Souza, None; Hideraldo Luis Souza Cabeça, None; Alexandre Rosa, None; Luiz Carlos Silveira, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1431. doi:
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      Lucas Daniel Fernandes, Phelipe Paixao, Lorena Botelho Vergara, Juliana Araujo, Eliza Maria Lacerda, Givago Souza, Hideraldo Luis Souza Cabeça, Alexandre Rosa, Luiz Carlos Silveira; Optical Coherence Tomography of the Optic Nerve: Comparison Between Multiple Sclerosis and Neuromyelitis Optica. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1431.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To compare the optical coherence tomography (OCT) of the optic nerve from patients with multiple sclerosis (MS) and neuromyelitis optica (NMO).

Methods: Patients with MS (n=5, 29.4 ± 2.88 years old) and NMO (n=10, 30.8 ± 8.27 years old) were tested with OCT. The following parameters were evaluated: average retinal nerve fiber layer (RNFL), nerve head volume, cup-disc area ratio, optic nerve head map of the superior (S), nasal (N), inferior (I) and temporal (T) regions. Both groups were compared to each other and to an age and gender-matched control group. Statistical analyses used: two-way ANOVA, Tukey's post hoc test, α=0.05.

Results: MS and NMO patients had average RNFL lower than the control (p<0.01), while there were no statistical difference between MS group and NMO group. There were no statistical differences between nerve head volume and cup-disc area ratio among the groups. The analysis of the optic nerve head topography provided no significant difference between MS group and NMO group (p>0.05), but the MS group had lower values than the control group in the superior, inferior and temporal regions (p<0.001). NMO group also showed lower results than the controls at all optic nerve regions.

Conclusions: The NMO and MS groups showed similar damage in the optic nerve. The values of nerve head volume and cup-disc area ratio were preserved in comparison to the control group. However, the values of average RNFL were reduced.

Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 613 neuro-ophthalmology: optic nerve • 629 optic nerve  
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