June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Multimodal retinal imaging in multiple sclerosis with and without optic neuritis
Author Affiliations & Notes
  • Elisabetta Pilotto
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Paolo Gallo
    Department of Neuroscience, University of Padova, Padova, Italy
  • Francesca Guidolin
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Enrica Convento
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Matteo Atzori
    Department of Neuroscience, University of Padova, Padova, Italy
  • Marco Puthenparampil
    Department of Neuroscience, University of Padova, Padova, Italy
  • Raffaele Parrozzani
    Department of Ophthalmology, University of Padova, Padova, Italy
    Fondazione G.B. Bietti per l’Oftalmologia, IRCCS, Roma, Italy
  • Edoardo Midena
    Department of Ophthalmology, University of Padova, Padova, Italy
    Fondazione G.B. Bietti per l’Oftalmologia, IRCCS, Roma, Italy
  • Footnotes
    Commercial Relationships Elisabetta Pilotto, None; Paolo Gallo, None; Francesca Guidolin, None; Enrica Convento, None; Matteo Atzori, None; Marco Puthenparampil, None; Raffaele Parrozzani, None; Edoardo Midena, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1432. doi:
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      Elisabetta Pilotto, Paolo Gallo, Francesca Guidolin, Enrica Convento, Matteo Atzori, Marco Puthenparampil, Raffaele Parrozzani, Edoardo Midena; Multimodal retinal imaging in multiple sclerosis with and without optic neuritis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1432.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To correlate multiple spectral domain OCT (SD-OCT) measures to microperimetric data in patients with multiple sclerosis (MS), with and without previous optic neuritis (ON).

Methods: Patients with relapsing-remitting MS, with and without history of ON, with uni-or bilateral pale optic disc were enrolled. Each patient was studied by SD-OCT (Spectralis HRA+OCT Heidelberg, Engineering, Heidelberg, Germany) to measure central retinal thickness, retinal nerve fibre layer thickness in the peripapillary area (pRNFL) and in the papillomacular bundle (PMB). Using dedicated SD-OCT software individual retinal layers were identified and measured (thickness) in the perifoveal area. Each patient underwent microperimetry (MP1 Microperimeter, Nidek, Gamagori, Japan) to assess retinal sensitivity in the peripapillary and macular area. All patients underwent a complete neurological and ophthalmological examination. An age-matched group of healthy subjects was used as control.

Results: Thirty-eight patients (mean age 37 ± 8 years; 25 female and 13 male; 76 eyes) with relapsing-remitting MS were enrolled: 19 patients had a history of at least one episode of ON (ON-MS), in 19 patients a pale optic disc was present at the fundus examination with no history of ON (POD-MS). The control group consisted of 20 healthy subjects (40 eyes) (mean age 36 ± 9 years). Mean pRNFL and PMB were significantly thinner in the MS patients versus controls (pRNFL: 89.83 ± 13.06 μm vs 97.83 ± 8.56, p= 0.021; PMB: 48.72 ± 11.17 μm vs 58.41 ± 5.89, p= 0.000). The retinal ganglion cell layer was significantly thinner in the ON-SM than in POD-MS patients (7 ± 4.9 μm vs 9.4 ± 2.3 μm, p= 0.0252). The reduction of mean retinal sensitivity, and peripapillary and macular sensitivity were significantly correlated to pRNFL and PMB thinning and to ON history. Retinal sensitivity reduction in the macular area was correlated to the thickening of the retinal outer plexiform layer.

Conclusions: MS induces variable changes inside the retina. These changes involve not only the inner retina, but also the outer retinal layers and are correlated to the reduction of retinal sensitivity. These findings suggest that retinal reorganization occurs after degeneration of individual retinal layers with secondary functional alterations.

Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 642 perimetry • 688 retina  
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