June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Optical Coherence Tomography imaging of Eyes with Optic Nerve Head Drusen
Author Affiliations & Notes
  • Taku Sato
    Vitreous Retina Macular Consultants of New York, New York, NY
    LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital,, New York, NY
  • Sarah Mrejen
    Vitreous Retina Macular Consultants of New York, New York, NY
    LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital,, New York, NY
  • Richard Spaide
    Vitreous Retina Macular Consultants of New York, New York, NY
    LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital,, New York, NY
  • Footnotes
    Commercial Relationships Taku Sato, Alcon Japan Ltd. (F); Sarah Mrejen, None; Richard Spaide, Topcon (P), Thrombogenics (C), Bausch and Lomb (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1439. doi:
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      Taku Sato, Sarah Mrejen, Richard Spaide; Optical Coherence Tomography imaging of Eyes with Optic Nerve Head Drusen. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1439.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate optic nerve head drusen (ONHD) using optical coherence tomography (OCT) methodologies that are capable of deeper tissue penetration and to determine associated retinal nerve fiber layer (RNFL) changes.

 
Methods
 

Eyes with ONHD unassociated with systemic disease were examined with enhanced depth imaging (EDI)-OCT, swept source OCT, and fundus autofluorescence. The greatest diameter, location and depth of each ONHD were determined and correlated with RNFL thickness measured using spectral domain OCT. Sectors of abnormal RNFL thickness were considered to be present if the thickness in that region was one percentile or less of the normographic values.

 
Results
 

Twenty-three eyes of 14 patients with ONHD were evaluated. The mean age was 64.1 years, and 8 were female. EDI-OCT and swept source OCT showed multiple ONHD of various sizes at different levels, all located anterior to the lamina cribrosa. The drusen were round, oval, or polymorphic regions of lower reflectivity that were bordered by hyperreflective material, and in 10 eyes (43.5%) there were internal hyperreflective foci. The mean±SD (range) diameter of the ONHD was 649.7 ± 352.3μm (range 226 to 1237 μm). There was a significant positive correlation between the diameter of the ONHD and the number of sectors of abnormal RNFL thickness (r = 0.45, P = 0.04), and a significant negative correlation between the diameter of the ONHD and the RNFL thickness (r = -0.48, P = 0.02). Eyes with ONHD located in the middle of the optic nerve did not have abnormal RNFL thicknesses, whereas 75% (15/20) of eyes with ONHD located on the side of the optic nerve canal had abnormal RNFL thickness (P = 0.03).

 
Conclusions
 

OCT imaging capable of deeper tissue penetration in eyes with ONHD showed size, location, and composition details not previously available using older imaging technologies. The size and location of the ONHD were directly correlated with associated RNFL abnormalities.

 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 504 drusen • 627 optic disc  
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