June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
retinal nerve fiber layer defect and its associations in Adult Chinese Population
Author Affiliations & Notes
  • Ya Xing Wang
    Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing, China
  • Liang ZhAO
    Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing, China
  • Jost Jonas
    Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing, China
    Medical Faculty Mannheim-Heidelberg, Mannheim, Germany
  • Liang Xu
    Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing, China
  • Footnotes
    Commercial Relationships Ya Xing Wang, None; Liang ZhAO, None; Jost Jonas, Allergan (C), MSD (C), Alimera (C), CellMed AG (P); Liang Xu, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1460. doi:
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    • Get Citation

      Ya Xing Wang, Liang ZhAO, Jost Jonas, Liang Xu, Beijing Eye Study Group; retinal nerve fiber layer defect and its associations in Adult Chinese Population. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1460.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To assess the retinal nerve fiber layer thickness (RNFLT) and to determine the prevalence of retinal nerve fiber layer defect (RNFLD) in adult Chinese population.

 
Methods
 

In the population-based Beijing Eye Study 2011, 3468 individuals with age no less than 50 years were enrolled. RNFLT was measured in 3247 participants (93.6%) by spectral domain optical coherence tomography (SD-OCT, Spectralis). RNFLT was measured by section and as a whole. RNFLD was defined as mean thickness below the 99th percentile of the age-associated nominative database by the built-in software.

 
Results
 

The mean RNFLT was 150.65±24.01μm temporal-inferiorly, 137.02±22.77μm temporal-superiorly, 116.72±24.61μm nasal-inferiorly, and 104.32±21.37μm nasal-superiorly. Mean global RNFLT (100.86±12.26μm) decreased with older age (P<0.001), residing in the urban area (P< 0.004), higher IOP (P= 0.033), longer axial length (P=0.001) and flatter anterior corneal curvature (P=0.001). RNFLD were detected in 589 eyes (9.2 %±0.36%) or in 446 subjects (13.9 % ±0.61%). The prevalence of RNFLD increased significantly with older age, and longer axial length. (Table1, 2) In multivariate analysis, the prevalence of RNFLD in all quadrants was positively associated with higher age (P=0.028), lower cognitive scores (P=0.023), lower best-corrected visual acuity (P=0.003) and longer axial length (P<0.001). RNFLD superiorly was positively associated with older age (P=0.01), lower cognitive score (P=0.011), higher concentration of HbA1C (P=0.013), and longer axial length (P<0.001). RNFLD inferiorly was associated with higher age (P=0.048), lower prevalence of hyperlipdemia (P=0.029), lower best-corrected visual acuity (P=0.001) and longer axial length (P<0.001).

 
Conclusions
 

The prevalence of RNFLD in adult Chinese by OCT was 13.9%. It was significantly associated with older age, lower cognitive scores, lower best-corrected visual acuity and longer axial length, and the associations of RNFLD in different quadrant varies. Part of RNFLD in population was attributed to systematic diseases. The significant increase of RNFLD with myopia hint that the nominative database built-in might have ignored the refraction-related characteristics of RNFL distribution.

  
Keywords: 629 optic nerve • 550 imaging/image analysis: clinical  
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