June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Characteristic findings of retinitis pigmentosa in polarization sensitive optical coherence tomography
Author Affiliations & Notes
  • Karin Kofler
    Dep. of Ophthalmology and Optometrie, Medical University of Vienna, Vienna, Austria
  • Matthias Bolz
    Dep. of Ophthalmology and Optometrie, Medical University of Vienna, Vienna, Austria
  • Bernhard Baumann
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Stefan Zotter
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ferdinand Schlanitz
    Dep. of Ophthalmology and Optometrie, Medical University of Vienna, Vienna, Austria
  • Philipp Roberts
    Dep. of Ophthalmology and Optometrie, Medical University of Vienna, Vienna, Austria
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Markus Ritter
    Dep. of Ophthalmology and Optometrie, Medical University of Vienna, Vienna, Austria
  • Christoph Hitzenberger
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Dep. of Ophthalmology and Optometrie, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships Karin Kofler, None; Matthias Bolz, None; Bernhard Baumann, Canon Inc. (F); Stefan Zotter, Canon Inc. (F); Ferdinand Schlanitz, None; Philipp Roberts, Canon Inc. (F); Michael Pircher, None; Markus Ritter, None; Christoph Hitzenberger, Canon Inc. (F), Canon Inc. (C); Ursula Schmidt-Erfurth, Alcon (C), Bayer Healthcare (C), Novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1477. doi:
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    • Get Citation

      Karin Kofler, Matthias Bolz, Bernhard Baumann, Stefan Zotter, Ferdinand Schlanitz, Philipp Roberts, Michael Pircher, Markus Ritter, Christoph Hitzenberger, Ursula Schmidt-Erfurth, Translational Research Group for Ophthalmic Imaging; Characteristic findings of retinitis pigmentosa in polarization sensitive optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1477.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Retinitis pigmentosa(RP) is a clinical and genetic heterogenic group of retinal diseases affecting rods and cones. Molecular investigations have shown that some of the responsible genes for RP are expressed in the photoreceptors and some in the retinal pigment epithelium (RPE). RPE and photoreceptors were analyzed by PS-OCT which is specially suited to reveal the integrity of the RPE. Thereby we expect to get further insight into pathomorphology and -physiology.

Methods: Twelve eyes of six patients with RP were imaged using a prototype of a PS OCT device. After obtaining best-corrected visual acuity (BCVA), the integrity of the RPE was evaluated using autofluorescence angiography (AFA), spectral domain OCT (Spectralis HRA+OCT) and PS-OCT.

Results: Some patients showed a hyperautofluorescent ring in AFA. In all patients of this group the outer layers representing the photoreceptors (inner-outer segment line, outer nuclear layer) were found in the foveal center. In SD OCT the reflectivity of the RPE lying beneath these still present photoreceptors did not differ from those areas around the fovea without photoreceptors. However, PS-OCT revealed a significant difference in the integrity of the RPE according to the scanning location. The hyperreflective area in AFA correlated with the border between preserved and irregular or absent RPE. Regarding the extension of the area of RPE alteration, there was a good correspondence between AFA and PS OCT-maps. In patients with a central accumulation of depolarizing RPE clusters no inner-outer segment line was found and the peripheral RPE was absent.

Conclusions: PS-OCT is capable of detecting the integrity of the RPE in cases of RP in a very precise way combining information that until now was obtained by two different techniques, SD-OCT and AFA. Based on this technique new insight into the condition of the RPE in the progression of RP can be gained and solid prognostic evaluation and new therapeutic strategies might be deducted.

Keywords: 696 retinal degenerations: hereditary • 701 retinal pigment epithelium • 550 imaging/image analysis: clinical  
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