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Chen Lu, Martin Kraus, Ireneusz Grulkowski, Jonathan Liu, Benjamin Potsaid, Vijaysekhar Jayaraman, Alex Cable, Joachim Hornegger, Jay Duker, James Fujimoto; Handheld High Speed 500 kHz Swept Source OCT Device Using a Micro Scanning Mirror. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1489.
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The objective of this study is to design and demonstrate a compact handheld OCT device for disease screening to enable early detection before visual impairment. In addition, a portable and compact OCT device enables applications ranging from imaging in pediatric and trauma patients, to military medicine and in remote or undeveloped areas.
A compact handheld OCT patient interface shown in Fig. 1(A-B) was developed using a micro-electromechanical system (MEMs) scanning mirror. An iris camera, fixation target, and LCD screen was included in the device. Subjects were scanned sitting with the back of their head supported on a headrest. Orthogonal scanned OCT volumes were acquired in 1.45 seconds per volume using swept source OCT with a vertical-cavity surface-emitting laser (VCSEL) light source at 1050 nm wavelength and 500 kHz axial scan rate. The two orthogonal raster scans were then post-processed with custom motion correction registration software and merged to increase the signal to noise.
Alignment of the device for proper OCT imaging typically required ~30 seconds with the aid of the iris camera and OCT preview scans. Adjusting the fixation target centers the OCT scan to a point between the macula and optic nerve head. Fig. 2(A) shows a 10mm x 10mm en face OCT fundus image from a registered volumetric OCT data set. Fig. 2(B-C) shows representative single cross sectional images. Fig. 2(D) shows a vertical cross section in the slow scan direction of the original volumetric data to compare the motion-corrected registered data.
A handheld OCT device has been built and tested to acquire wide-field OCT volumetric scans that when registered, generate a single motion-corrected OCT volumetric data set. Volumetric OCT provides both a motion corrected fundus image as well as comprehensive cross sectional information on the macula and optic nerve head.
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