June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
VCSEL Laser Technology for Ultrahigh Speed and Extended Depth Range OCT Imaging of the Retina and Anterior Eye
Author Affiliations & Notes
  • Benjamin Potsaid
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Instiute of Technology, Cambridge, MA
    Advanced Imaging Group, Thorlabs, Newton, NJ
  • Jonathan Liu
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Instiute of Technology, Cambridge, MA
  • WooJhon Choi
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Instiute of Technology, Cambridge, MA
  • Ireneusz Grulkowski
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Instiute of Technology, Cambridge, MA
  • Vijaysekhar Jayaraman
    Praevium Research Inc., Santa Barbara, CA
  • James Jiang
    Advanced Imaging Group, Thorlabs, Newton, NJ
  • Peter Heim
    Advanced Imaging Group, Thorlabs, Newton, NJ
  • Jay Duker
    New England Eye Center and Tufts Medical Center, Tufts University, Boston, MA
  • Alex Cable
    Advanced Imaging Group, Thorlabs, Newton, NJ
  • James Fujimoto
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Instiute of Technology, Cambridge, MA
  • Footnotes
    Commercial Relationships Benjamin Potsaid, Thorlabs, Inc. (E), Optovue, Inc. (P); Jonathan Liu, None; WooJhon Choi, None; Ireneusz Grulkowski, None; Vijaysekhar Jayaraman, Praevium Research, Inc. (E), Thorlabs, Inc. (F); James Jiang, None; Peter Heim, Thorlabs, Inc. (E); Jay Duker, Carl Zeiss Meditech (F), OptoVue (F), Optos (C); Alex Cable, None; James Fujimoto, Carl Zeiss Meditec (P), Optovue (P), Optovue (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1491. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Benjamin Potsaid, Jonathan Liu, WooJhon Choi, Ireneusz Grulkowski, Vijaysekhar Jayaraman, James Jiang, Peter Heim, Jay Duker, Alex Cable, James Fujimoto; VCSEL Laser Technology for Ultrahigh Speed and Extended Depth Range OCT Imaging of the Retina and Anterior Eye. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1491.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

MEMS tunable Vertical Cavity Surface Emitting Laser (VCSEL) technology achieves a combination of ultrahigh sweep speeds, wide spectral tuning range, adjustability in sweep trajectory, and extremely long coherence length, which cannot be simultaneously achieved with any other OCT light source technology. This investigation demonstrates the unique advantages of the VCSEL for ultrahigh speed, ultralong depth range, and phase sensitive ophthalmic OCT imaging at 1065nm and 1310nm wavelengths.

 
Methods
 

A reconfigurable 1065nm swept source/Fourier domain prototype OCT instrument with 20kHz -1.2MHz axial scan rate was developed to perform retinal and anterior segment imaging, as well as full eye length measurement. A second instrument operating at 1310nm was developed to perform anterior segment imaging.

 
Results
 

The high speeds of the VCSEL enable acquisition of wide field, densely sampled retinal volumes with minimal motion artifacts (Fig. 1A). The record coherence length of the VCSEL enables long depth range imaging (Fig. 1B). It is possible to acquire single data sets extending from the cornea to the retina using an ultralong depth range imaging mode. Using phase sensitivity OCT, quantitative Doppler blood flow information can be obtained at high acquisition speeds to capture fast flow (Fig. 2A and 2B). Doppler angiography techniques to visualize capillaries can also be performed by using the high axial scan speeds.

 
Conclusions
 

MEMS tunable VCSEL technology for Swept Source OCT exhibits a unique combination of high imaging speed, adjustablity in operating parameters, and long imaging range, which promises to improve visualization of disease relevant ocular features, enable new OCT imaging capability, and improve patient work flow in the clinic by allowing multipurpose OCT imaging instrumentation.

 
 
Figure 1. (A) Large area 12x12mm 3D data set of the retina obtained at 1.2MHz axial scan rate with a 1065nm VCSEL. (B) Long Depth range cross sectional image obtained at 100kHz axial scan rate with 1310nm VCSEL.
 
Figure 1. (A) Large area 12x12mm 3D data set of the retina obtained at 1.2MHz axial scan rate with a 1065nm VCSEL. (B) Long Depth range cross sectional image obtained at 100kHz axial scan rate with 1310nm VCSEL.
 
 
Figure 2. (A) Intensity and (B) Doppler OCT cross sectional image showing blood flow in the optic nerve head obtained at 400kHz axial scan rate with a 1065nm VCSEL.
 
Figure 2. (A) Intensity and (B) Doppler OCT cross sectional image showing blood flow in the optic nerve head obtained at 400kHz axial scan rate with a 1065nm VCSEL.
 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 688 retina • 421 anterior segment  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×