June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Ultrahigh speed polarization sensitive OCT of the anterior and posterior eye using a 1050 nm VCSEL light source
Author Affiliations & Notes
  • Al-Hafeez Dhalla
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, MIT, Cambridge, MA
    Ophthalmology, New England Eye Center and Tufts Medical Center, Boston, MA
  • Jonathan Liu
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, MIT, Cambridge, MA
  • Kathrin Mohler
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, MIT, Cambridge, MA
  • Benjamin Potsaid
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, MIT, Cambridge, MA
    Advanced Imaging Group, Thorlabs, Newton, NJ
  • Chen Lu
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, MIT, Cambridge, MA
  • Vijaysekhar Jayaraman
    Praevium Research, Inc., Santa Barbara, CA
  • Alex Cable
    Advanced Imaging Group, Thorlabs, Newton, NJ
  • David Huang
    Casey Eye Institute, Oregon Health & Science University, Portland, OR
  • James Fujimoto
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, MIT, Cambridge, MA
  • Footnotes
    Commercial Relationships Al-Hafeez Dhalla, Bioptigen (P); Jonathan Liu, None; Kathrin Mohler, None; Benjamin Potsaid, Thorlabs, Inc. (E), Optovue, Inc. (P); Chen Lu, None; Vijaysekhar Jayaraman, Praevium Research, Inc. (E), Thorlabs, Inc. (F); Alex Cable, None; David Huang, Optovue (F), Optovue (I), Optovue (P), Optovue (R), Carl Zeiss Meditec (P); James Fujimoto, Carl Zeiss Meditec (P), Optovue (P), Optovue (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1492. doi:
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    • Get Citation

      Al-Hafeez Dhalla, Jonathan Liu, Kathrin Mohler, Benjamin Potsaid, Chen Lu, Vijaysekhar Jayaraman, Alex Cable, David Huang, James Fujimoto; Ultrahigh speed polarization sensitive OCT of the anterior and posterior eye using a 1050 nm VCSEL light source. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1492.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

We demonstrate high-speed polarization sensitive optical coherence tomography (PSOCT) of both the anterior and posterior eye using a vertical cavity surface emitting laser (VCSEL) light source at 1060nm with an imaging rate of 200-290kHz.

 
Methods
 

Swept source (SS-) PSOCT imaging was performed in the anterior and posterior eye by using two orthogonal, time-encoded incident polarization states and detecting two polarization channels with an all-fiber, polarization-sensitive balanced receiver. The VCSEL enabled ultrahigh speed imaging with adjustable range that could be optimized for anterior eye and retinal applications. For anterior eye imaging, the VCSEL was configured to enable a 290kHz imaging rate, providing an axial resolution of 40µm over a depth range of 25mm. The two incident polarization states were time encoded with a 12mm delay. Intensity images and birefringence maps of the entire anterior segment were acquired at a rate of 72.5Hz for images of 4000 A-lines/image. For retinal imaging, the VCSEL was configured to tune at 200kHz, enabling an axial resolution of 12µm over a depth range of 4.5mm. Wide-field 3D data sets comprising 1000 x 1000 A-scans were recorded, from which both intensity images and retardance maps of the retina were extracted.

 
Results
 

SS-PSOCT using a VCSEL enables integrated structural and polarization sensitive imaging of the entire anterior chamber from the cornea to the posterior lens. In the retina, wide-field volumetric structural and retardance data can be acquired. Fig 1 and 2 show examples of structural and retardance images of the anterior segment and retina

 
Conclusions
 

The flexibility, high speed and long imaging range of the VCSEL make it the ideal light source for PS-OCT. The long imaging range enables PS-OCT imaging of the entire anterior chamber, while the adjustable speed enables wide field volumetric imaging of the retina.

 
 
Structural OCT (top) and PSOCT (bottom) images of the anterior segment from cornea to posterior lens surfaces. Retardance map is scaled blue = 0 degrees to red = 90 degrees. 4000 Ascans x 10 averaged frames, acquired in 0.14 seconds.
 
Structural OCT (top) and PSOCT (bottom) images of the anterior segment from cornea to posterior lens surfaces. Retardance map is scaled blue = 0 degrees to red = 90 degrees. 4000 Ascans x 10 averaged frames, acquired in 0.14 seconds.
 
 
Left: En face view of widefield 3D PSOCT data set comprising 1000 x 1000 A-scans, acquired in 5 seconds. Right: wide field structural (top) and PS-OCT (bottom) images extracted from the same data set shown to the right. 1000 Ascans x 10 averaged frames, acquired in 0.05 seconds.
 
Left: En face view of widefield 3D PSOCT data set comprising 1000 x 1000 A-scans, acquired in 5 seconds. Right: wide field structural (top) and PS-OCT (bottom) images extracted from the same data set shown to the right. 1000 Ascans x 10 averaged frames, acquired in 0.05 seconds.
 
Keywords: 688 retina • 420 anterior chamber • 701 retinal pigment epithelium  
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