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Roxanne Crosby-Nwaobi, Angus Forbes, Sobha Sivaprasad, South East London Diabetic Retinopathy study; Factors that contribute to vision-related quality of life scores in patients with diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1544.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the impact of severity of diabetic retinopathy (DR), visual acuity and diabetes related stress on vision related quality of life in patients with diabetic retinopathy.
372 men and women with T2D were stratified by severity of DR into no retinopathy and proliferative diabetic retinopathy (PDR). Each subject underwent tests of diabetes related distress (PAID), vision-related quality of life (NEI-VFQ25), best corrected visual acuity (BCVA)[logMAR], ophthalmic and physical examination. Bivariate analysis between categories of DR; linear regression was conducted for the NEI-VFQ-25 by DR severity adjusting for age, gender, HbA1c and PAID were conducted using SPSS v17.
The mean NEI-VFQ-25 for the PDR group was significantly lower when compared to the group with no retinopathy, 86.2±10.7 vs. 75.8±20.4, p=<0.001, where lower score=decreased vision-related quality of life. BCVA (0.09±0.13 vs. 0.19±0.21, p< 0.001) and HbA1c (8.0±1.8 vs. 8.7±2.0, p=0.007) were also significantly different between the two groups of retinopathy. PAID was not significant between the groups. NEI-VFQ-25 was inversely correlated to logMAR BCVA (r=-0.052, p<0.001) and PAID (r=-0.219, p<0.001). Gender differences were found for NEI-VFQ-25 by DR severity; men showed significantly higher NEI-VFQ-25 scores when compared to women (no retinopathy: 88.8±9.5 vs. 88.3±11.3, p=0.002 and PDR: 79.4±19.7 vs. 71.4±20.4, p=0.030). On full adjustment of the model, NEI-VFQ-25 was significantly associated with severity of retinopathy (no retinopathy: 84.3±1.1 vs. PDR: 79.0±191.2, p<0.001) with BCVA accounting for 20% of the variance in the model.
NEI-VFQ-25 is independently associated with severity of DR and visual acuity only accounts for 20% of the variance.
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